If you experience any adverse reactions after taking collagen, stop taking it and speak to your CMJ height recovered quicker with CP than CON at 48 h (P = 0.050; CP 89.96 12.85 vs. CON 78.67 14.41% of baseline values; ES = 0.55). Int J Sport Nutr Exerc Metab. Does eating these foods increase levels of collagen in the body? The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 2023 Jan;13(1):e2820. Before Can Collagen Cause Diarrhea? WebCollagen peptides are made by breaking down whole collagen proteins into smaller pieces. 2020;12(3):618.View abstract. Dizziness. It is believed that adding more collagen to your diet could potentially cause a deficiency in tryptophan. 2011;35(3):341-8. Learn more. Ingredients such as dyes and synthetic gelatin found in gummy supplements can be difficult to digest, leading to inflammation of the gut. While we have no reports of ProT Gold users experiencing headaches or migraines after using our collagen products, preliminary research into the topic suggests that there may be a correlation between some collagen supplements and headaches., Whether collagen can cause headaches or not often is dependent on the person taking the supplement, the dosage, the type of collagen, and the supplement quality itself., If you suspect that your supplemental collagen can cause headaches or migraines, then exploring why you have this reaction and how to prevent it will be the first place to start., Before we get into whether collagen can cause headaches, lets look at the overall safety of collagen supplements in general., If youre asking the question: can collagen cause headaches? You are probably also interested in other possible side effects of collagen, and if collagen is a safe supplement to take., Its hard to answer whether collagen can cause headaches and if the supplement itself is safe, simply because the FDA does not regulate most supplements., Since there is such limited regulation of supplements on the market, this leads to immense skepticism regarding how safe they really are and what side effects they cause., The lack of regulation when it comes to supplements versus drugs means that not all supplement companies necessarily have to prove their claims., So, if they are simply trying to sell a product to the consumer, they do not have to have evidence to support whether or not the collagen supplement they are providing actually will benefit the consumer, or whether their supplemental collagen can cause headaches or other issues., Still, the FDA does recognize ingestible collagen as Generally Recognized As Safe (GRAS)., There have been specific collagen supplements that have been recalled by the FDA for safety reasons, which is why it is important to buy from a reputable brand., For instance, our liquid collagen supplement, ProT Gold, is actually recognized as a medical food, which is why it has a nutritional label, not a supplement label., Because of this, ProT Gold is also trusted by over 3,000 medical facilities and used widely for medical nutrition therapy., Something that should be recognized about collagen as a supplement is that it is natural. Molecules 2021;26(16):4880. You can learn more about how we ensure our content is accurate and current by reading our. Cochrane Database Syst Rev. If you buy through links on this page, we may earn a small commission Heres our process. WebGlutamate is implicated in cortical spreading depression, trigeminovascular activation, and central sensitization. Main benefits: Provides moisture to the skin and scalp, strengthens the hair follicle, accelerates healing, and nourishes the hair bulb. This site needs JavaScript to work properly. Effect of the novel low molecular weight hydrolyzed chicken sternal cartilage extract, BioCell Collagen, on improving osteoarthritis-related symptoms: a randomized, double-blind, placebo-controlled trial. These chemical ingredients can cause systemic inflammation as well as accumulate within the body, leading to enlarged and clogged pores, and ultimately more breakouts. Siahaan EA, Agusman, Pangestuti R, Shin KH, Kim SK. Urinary Metabolomics in Young Soccer Players after Winter Training Season. Would you like email updates of new search results? Potential Cosmetic Active Ingredients Derived from Marine By-Products. Some peptides are antimicrobial, meaning they can kill View abstract. Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women-A Randomized Controlled Study. Many are available to buy online. Sangsuwan W, Asawanonda P. Four-weeks daily intake of oral collagen hydrolysate results in improved skin elasticity, especially in sun-exposed areas: a randomized, double-blind, placebo-controlled trial. Having high levels of calcium in your blood is also known as hypercalcemia and seems to be more predominantly an issue in women., Too much calcium can also cause some skin rashes and other symptoms overlapping with side effects with collagen., One way to determine if calcium is the cause of your headaches or if taking a collagen supplement is raising your blood calcium levels is to get a blood test for calcium. Rheumatoid arthritis, lupus, dermatomyositis and scleroderma are autoimmune, connective tissue diseases known to damage collagen. We include products we think are useful for our readers. 2010;35(6):797-804. Creams have the advantage of providing extra hydration, making them particularly suitable for dry, wrinkled, or aging skin, and they pose even fewer risks than the already rare potential side effects of oral supplements. Pressure ulcer healing with a concentrated, fortified, collagen protein hydrolysate supplement: a randomized controlled trial. We avoid using tertiary references. OTHER NAME(S): Collagen Hydrolysate, Collagen Peptidesi, Collagn, Collagen peptides have most often been used by adults in doses of 2.5-10 grams daily for up to 6 months. View abstract. Sugihara F, Inoue N, Venkateswarathirukumara S. Ingestion of bioactive collagen hydrolysates enhanced pressure ulcer healing in a randomized double-blind placebo-controlled clinical study. Epub 2019 Aug 14. Glutamate receptor-subtype antagonists are effective in preclinical models of migraine, and in the clinic. official website and that any information you provide is encrypted View abstract. As well, since the FDA considers collagen a dietary supplement, the safety and effectiveness of collagen peptide supplements are also unregulated. Taking collagen supplements as a healthcare professional directs is generally safe. Lopez HL, Ziegenfuss TN, Park J. However, these claims do not have backing by scientific research. MeSH Epub 2022 Jul 23. 2006;19(2):92-6. J Sci Food Agric. According to a few case studies on using collagen to treat osteoarthritis, when participants were using the collagen supplement, they did report a lower pain level in their There is some evidence to suggest that using collagen supplements may help increase muscle mass. Hexsel D, Zague V, Schunck M, Siega C, Camozzato FO, Oesser S. Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails. View abstract. Int J Sport Nutr Exerc Metab 2021. Unable to load your collection due to an error, Unable to load your delegates due to an error. This in turn, can lead to a number of side effects, including abnormal heart rhythms. Glutamate receptor-subtype antagonists are effective in preclinical models of migraine, and in the clinic. The oral supplementation with collagen peptides is efficacious to improve hallmarks of skin aging. View abstract. Information from this source is evidence-based and objective, and without commercial influence. View abstract. Type of ingredient: Hydrator and strengthener 4. Unauthorized use of these marks is strictly prohibited. 2010;340(5):360-6. Federal government websites often end in .gov or .mil. Li X, He Z, Xu J, Su C, Xiao X, Zhang L, Zhang H, Li H. Foods. Zhu CF, Li GZ, Peng HB, Zhang F, Chen Y, Li Y. For most people, taking collagen peptide supplements should not have any major effects or health consequences, and topical collagen peptide products in particular are unlikely to pose a risk. Muscle soreness was not significantly different in CP and CON (P = 0.071) but a large effect size was evident at 48 h post-exercise, indicative of lower soreness in the CP group (90.42 45.33 mm vs. CON 125.67 36.50 mm; ES = 2.64). View abstract. Though this study is promising, more research is necessary to fully determine the positive effects that collagen may have on muscle growth. Lis DM, Baar K. Effects of Different Vitamin C-Enriched Collagen Derivatives on Collagen Synthesis. pii: E482. Accessibility 2019 Mar 4. The less your body has to work to break down the collagen when you consume it, the less likely you are to get a stomach ache or other unwanted side effects. Therapeutic effects of marine collagen peptides on Chinese patients with type 2 diabetes mellitus and primary hypertension. Collagen makes up a significant amount of bone structure and helps keep the bones strong. 2018;10(7).View abstract. Apart from fatigue, this might lead to headaches and feelings of nervousness and irritability. Clark KL, Sebastianelli W, Flechsenhar KR, et al. Choi SY, Kim WG, Ko EJ, et al. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. Bagheri Miyab K, Alipoor E, Vaghardoost R, et al. Two placebo-controlled clinical trials were run to assess the effect of a daily oral supplementation with collagen peptides on skin hydration by corneometry, on collagen density by high-resolution ultrasound and on collagen fragmentation by reflectance confocal microscopy. Disclaimer. Benefits of Circulating Human Metabolites from Fish Cartilage Hydrolysate on Primary Human Dermal Fibroblasts, an Ex Vivo Clinical Investigation for Skin Health Applications. 2016;96(12):4077-81. The ingredients list is going to be very telling when looking at any supplement., Consider if there are several additives or unnatural ingredients. Burns. Protein and Sport: Alternative Sources and Strategies for Bioactive and Sustainable Sports Nutrition. and transmitted securely. Nutrients. As with any supplement, collagen supplements do have some potential side effects, especially when taken in excess. Drugs. pii: E892. Collagen supplements are available in the form of tablets, capsules, and powders. Collagen is a protein that our body already produces, , so when taking it in a supplement form, you are replenishing your collagen stores with animal-based collagen., Beyond the product itself and ingredients, dosage can also impact, how safe it is to use collagen as a daily supplement, Digestive upset such as bloating and nausea, Allergic reactions and general collagen sensitivities, when participants were using the collagen supplement, they did report a lower pain level in their joints but among the most commonly reported side effects was a headache from time to time., However, one common trend we found in our research for this article is that the type of collagen and quality of the supplement itself contributes a lot to the, potential for side effects like headaches, It has been considered that collagen may cause headaches for some users because it can raise your calcium levels. Topical application and oral supplementation of peptides in the improvement of skin viscoelasticity and density. Whether used as a powder in smoothies or as oral supplements, collagen has all the rage nowadays. Arch Dermatol. WebCollagen is a protein responsible for healthy joints and skin elasticity, or stretchiness. Knight, J., Jiang, J., Assimos, D. G., & Holmes, R. P. (2006). (2016). https://webprod5.hc-sc.gc.ca/lnhpd-bdpsnh/info.do?licence=80034311&lang=eng. However, more research is necessary to prove the effects of collagen in supporting heart health. National Library of Medicine It's possible to be sensitive or allergic to certain collagen Effect of dietary supplementation with collagen hydrolysates on bone metabolism of postmenopausal women with low mineral density. Speak with a, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, Osteoarthritis. Maturitas. Appl Physiol Nutr Metab. IMPORTANT NOTE: Looking for fruits that help to relieve constipation? Urinary Hydroxyproline Is Only Suitable As a Biomarker for Acute Intake, Up to 6 hr Postingestion of Collagen Proteins in "Free-Living," Healthy, Active Males. Apweiler E, Wallace D, Stansfield S, Allerton DM, Brown MA, Stevenson EJ, Clifford T. Sports (Basel). If you take more collagen than your body can digest, it will cause problems adapting the body to new levels of energy. In this study, the women took either a collagen supplement or placebo for 8 weeks. Jung K, Kim SH, Joo KM, et al. Something that should be recognized about collagen as a supplement is that it is natural. Effects of a chicken collagen hydrolysate on the circulation system in subjects with mild hypertension or high-normal blood pressure. 2019;29(5):461-465. 2008 May;144(5):666-72. doi: 10.1001/archderm.144.5.666. View abstract. Alipoor E, Hosseinzadeh-Attar MJ, Salehi S, et al. The .gov means its official. Although they are most popularly used to combat the signs of aging in the skin, collagen peptides can provide a number of other potential benefits as well. Enhanced Skin Permeation of Anti-wrinkle Peptides via Molecular Modification. Testing the Role of Glutamate NMDA Receptors in Peripheral Trigeminal Nociception Implicated in Migraine Pain. Webcan collagen supplements cause headaches? Elam ML, Johnson SA, Hooshmand S, et al. J Dermatol Sci. Expert Opin Investig Drugs. Its always something 2016;2016:4389410. Its always best to speak with your doctor when beginning to take new supplements, particularly in order to avoid adverse interactions with medications. View abstract. View abstract. This site needs JavaScript to work properly. View abstract. Cardiovascular health: Insomnia linked to greater risk of heart attack. Int Orthop. The site is secure. Most collagen users do not experience any adverse effects when taking a high-quality collagen supplement at the proper dosage. Bauza E, Oberto G, Berghi A, Dal CF, Domloge N. Collagen-like peptide exhibits a remarkable antiwrinkle effect on the skin when topically applied: in vivo study. We do not provide medical diagnosis, advice, or treatments. Disease- and headache-specific microRNA signatures and their predicted mRNA targets in peripheral blood mononuclear cells in migraineurs: role of inflammatory signalling and oxidative stress. Theres currently 80 approved peptide drugs worldwide. Nutrients. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Taking collagen peptides by mouth might slightly relieve pain and improve joint function in people with. One thing that you can look for is a medical grade collagen supplement like ProT Gold., It is still a possibility that you may experience some side effects with any collagen supplement. Clipboard, Search History, and several other advanced features are temporarily unavailable. So, it is important to get to know proper dosage of collagen for your body and nutritional needs., No matter the supplement that you decide to use, there is always a potential for side effects or adverse reactions. 2015;8:29-42. Camilion JV, Khanna S, Anasseri S, Laney C, Mayrovitz HN. The Bone Biomarker Response to an Acute Bout of Exercise: A Systematic Review with Meta-Analysis. 2021;20(1):188-194. Mar Drugs. 2015;95(4):702-7. Although some experts believe that peptide skin creams or moisturizers are not able to be absorbed fully via the skin, instead recommending oral supplements, some research has nonetheless shown them to have positive effects on skin health. What are L-tryptophan supplements? The site is secure. Zmitek K, Zmitek J, Rogl Butina M, Pogacnik T. Effects of a combination of water-soluble coenzyme Q10 and collagen on skin parameters and condition: Results of a randomised, placebo-controlled, double-blind study. A randomized double blind clinical pilot trial evaluating the safety and efficacy of hydrolyzed collagen type II in adults with osteoarthritis. Another similar study in the journal Skin Pharmacology and Physiology looked at the effects of collagen supplements on womens skin. As a person ages and collagen production slows, bones can become weaker as the person loses the collagen necessary to keep the bones strong and supported. Collagen powder can sometimes have a bad taste but can be blended into a smoothie, while pills have the benefit of being tasteless but are generally large in size. Biol Pharm Bull. Efficacy and Safety of Topical or Oral Hydrolyzed Collagen in Women with Dermatoporosis: A Randomized, Double-Blind, Factorial Design Study. View abstract. Many people know collagen for its role in supporting skin health and vitality. The vegan options may not be available everywhere, but many are available online. Collagen is one of the most plentiful proteins in mammals. View abstract. However, it is important to understand what collagen and biotin are and what research is available to support these claims. 2018;17(2):298-304. They accomplish this by stimulating new collagen growth, in turn reducing wrinkles, boosting skin elasticity, and improving skin hydration. If youre in a state of chronic migraine or get attacks often, I recommend avoiding collagen peptides unless its prescribed by your physician. Zdzieblik D, Oesser S, Baumstark MW, Gollhofer A, Knig D. Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. Type 1: This is one of the most abundant types present in the human body and helps support healthy skin. An official website of the United States government. 8600 Rockville Pike Int J Environ Res Public Health 2021;18(9):4837. Prokopov A, Pavlackov J, Mokrejs P, Gl R. Collagen Hydrolysate Prepared from Chicken By-Product as a Functional Polymer in Cosmetic Formulation. However, it is possible to have too much of a good thing., If calcium is the cause of your collagen-related headache problems, then a simple change in collagen supplement dosage may be in order to reduce the likelihood that your collagen can cause headaches., If you are worried about or already are experiencing headaches from your collagen supplements then it is best to consult a medical professional. Collagen supplements have the potential to cause both headaches and migraines. Many believe that collagen supplements can help reduce the effects of aging, such as by adding moisture to the skin, reducing wrinkles, and improving elasticity. Molecules 2021;26(7):2021. WebCollagen type II (native) is a protein that is part of the cartilage, bone, and other types of connective tissues in animals and humans. Praet SFE, Purdam CR, Welvaert M, et al. It is made up of amino acids which build our skin, connective tissue, organs, and bones and plays a role in forming the fibroblasts (cell clusters) which allow new cells to grow and replace dead ones. 2009;60 Suppl 2:99-113. Adv Skin Wound Care. Nutrients. Effect of collagen hydrolysate in articular pain: a 6-month randomized, double-blind, placebo controlled study. 2020:1-6. Updated February 27, 2014. 2020;111(3):708-718. 2000;30(2):87-99. * "It Peptides are also used in So, these additional things are more often associated with certain side effects like an upset stomach. 2017 Dec 14;12(12):CD009789. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Migraine pain-relay centers, including the trigeminal ganglion, trigeminal nucleus caudalis, and thalamus, contain glutamate-positive neurons, and glutamate activates the trigeminal nucleus caudalis. Kynurenines and PACAP in Migraine: Medicinal Chemistry and Pathogenetic Aspects. The protein collagen has 3 essential amino acids that decrease constipation, helps with leaky gut syndrome, and even reduces diarrhea. If you have a history of calcium oxalate kidney stones, exercise caution when incorporating collagen peptides by beginning with no more than about 1 tablespoon per day, and always stay well-hydrated. But does collagen have any side effects, and can collagen cause headaches?. As mentioned, collagen is a large protein that contains many different peptides and amino acids. Int J Sport Nutr Exerc Metab. View abstract. However, such claims do not yet have scientific evidence to support them. Treatment with marine collagen peptides modulates glucose and lipid metabolism in Chinese patients with type 2 diabetes mellitus. Before View abstract. An official website of the United States government. FOIA 2022 Sep 16;11(18):2869. doi: 10.3390/foods11182869. For more in-depth resources about vitamins, minerals, and supplements, visit our dedicated hub. Asserin J, Lati E, Shioya T, Prawitt J. Taking collagen supplements may also help support a healthy cardiovascular system. Clin Interv Aging. To protect collagen stores, doctors recommend you use a broad-spectrum sunscreen with an SPF of 30 or higher every day, refrain from, Topical creams which include retinoic acid or, Despite the well-known risks of exposure to. That being said, we want to point out that these side effects are not common. Biosci Rep. 2018 Dec 14;38(6):BSR20181347. Yamamoto S, Deguchi K, Onuma M, Numata N, Sakai Y. Absorption and Urinary Excretion of Peptides after Collagen Tripeptide Ingestion in Humans. It is advisable to cautiously watch your collagen intake as excessive consumption often leads to some mild reactions. eCollection 2022 Aug. View abstract. Accessed January 15, 2015. The participants study took 15 grams (g) of collagen or a placebo pill per day. This means that the manufacturer has broken the collagen in the supplements down into peptides, making it easier for the body to absorb and use. The reasons why headaches are a potential side effect of collagen are variable and not necessarily conclusive, as more research is needed on this topic., However, one common trend we found in our research for this article is that the type of collagen and quality of the supplement itself contributes a lot to the potential for side effects like headaches., It has been considered that collagen may cause headaches for some users because it can raise your calcium levels. The https:// ensures that you are connecting to the When choosing your collagen peptides supplement, be sure its manufacturer hasnt been called out by the FDA. Of those side effects, there has been a recurring theme among many collagen users asking: For instance, our liquid collagen supplement, ProT Gold, is actually recognized as a medical food, which is why it has a, nutritional label, not a supplement label. 2010;65(3):253-7. Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. 2015;18(3):324-31. Clin Exp Dermatol. 2015;14(3):30-8. Using a double-blind, independent group's design, 24 recreationally active males consumed either 20 g day-1 of CP or a placebo control (CON) for 7 days before and 2 days after performing 150 drop jumps. Zdzieblik D, Oesser S, Knig D. Specific Bioactive Collagen Peptides in Osteopenia and Osteoporosis: Long-Term Observation in Postmenopausal Women. ProT Powder Collagen Protein - 32 Servings. Before 2019;12(1):50. 2018;10(1). Also, Collagen Peptides supplements have not been found to cause any significant health risks for the majority of consumers. 2015 Dec;14(4):291-301. Rheumatoid arthritis, lupus, dermatomyositis and scleroderma are autoimmune, connective tissue diseases known to damage collagen. The information on our website is intended for educational purposes only. These preclinical and clinical observations argue for a strong link between migraine and the glutamatergic system, a link that is important to further characterize in an effort to better understand migraine mechanisms and deliver effective therapies. J Bone Metab 2021;28(3):207-213. Always take your collagen peptide supplements as instructed by a healthcare professional or as directed on the label of a product. 2015;114(8):1237-45. 2018;13(4):438-52. Skin Pharmacol Physiol. Chemical additives in collagen peptide supplements, such as anti-caking substances and preservatives are common causes of acne flare-ups in those who notice increased breakouts with collagen use. Your body makes collagen naturally, but you can also consume it through collagen supplements Skin Pharmacol Physiol 2021;34(3):115-127.View abstract. Kim HY, Lee JD, Lee YH, Seo SW, Lee HS, Kim S, Kim KB. Mood alteration: If you already have any type of mood disorder or imbalance in serotonin, collagen may impact how you feel. View abstract. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. Role of collagen hydrolysate in bone and joint disease. Oral Intake of Enzymatically Decomposed AP Collagen Peptides Improves Skin Moisture and Ceramide and Natural Moisturizing Factor Contents in the Stratum Corneum. A small study of 53 men revealed the positive effects of taking collagen supplements when exercising. For example, in a study in the Journal of Medical Nutrition and Nutraceuticals, several women drank a mixture containing various vitamins, minerals, hydrolyzed collagen, and hyaluronic acid. Epub 2022 Dec 22. In particular, the spongy cartilage of the joints starts to wear away. As with any supplement, collagen supplements do have some potential side effects, especially when taken in excess. Collagen peptides (also known as hydrolyzed collagen) are a shorter, broken down version of collagen that is more easily absorbed by your body than regular collagen supplements, and thus more effective. Collagen loss with age can cause increased tooth sensitivity and decreased tooth strength. Metabolites. Additional research is necessary to fully prove the effects that collagen has on promoting strong bones, however. Effects of a nutritional supplement containing collagen peptides on skin elasticity, hydration and wrinkles. Clipboard, Search History, and several other advanced features are temporarily unavailable. Collagen peptide supplements usually come in the form of either powders or pills and are generally considered equally safe and effective for skin care purposes. 2015;14(4):291-301. J Agric Food Chem. The study showed that compared with those in the control group, the women who drank this mixture reduced the depth of their wrinkles significantly. Recent Advances in Pharmacotherapy for Migraine Prevention: From Pathophysiology to New Drugs. View abstract. J Cosmet Dermatol. The researchers theorized that collagen helped stimulate the production of the proteins responsible for muscle growth. Argyrou C, Karlafti E, Lampropoulou-Adamidou K, et al. MNT is the registered trade mark of Healthline Media. From arthritis, to skin health, to post surgery healing, a quality collagen supplement can do wonders for your body. Inoue N, Sugihara F, Wang X. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study. Biosci Biotechnol Biochem. Hydroxyproline ingestion and urinary oxalate and glycolate excretion. sharing sensitive information, make sure youre on a federal What exactly is the reason collagen can cause a headache? 2020;46(1):156-163. Lis DM, Jordan M, Lipuma T, Smith T, Schaal K, Baar K. Collagen and Vitamin C Supplementation Increases Lower Limb Rate of Force Development. The following are the most common types of collagen a person can find in stores or online: Most supplements will contain several of these, and possibly other, types of collagen. Results: Effects of collagen peptides on recovery following eccentric exercise in resistance-trained males-A pilot study. WebClinical research has also shown that daily supplementation with collagen peptides can increase bone mineral density, especially in calcium-deficient or osteopenic subjects 7. Tajti J, Szok D, Nagy-Grocz G, Tuka B, Petrovics-Balog A, Toldi J, Vecsei L. Curr Med Chem. View abstract. Conclusions and Relevance: Preliminary results are promising for the short and long-term use of oral collagen supplements for wound healing and skin aging. 2017;24(13):1332-1349. doi: 10.2174/0929867324666170227115019. Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. Insulin is an example of a peptide drug, which is composed of 51 amino acids. Lin P, Alexander RA, Liang CH, et al. Saiga-Egusa A, Iwai K, Hayakawa T, Takahata Y, Morimatsu F. Antihypertensive effects and endothelial progenitor cell activation by intake of chicken collagen hydrolysate in pre- and mild-hypertension. Most collagen supplements are not vegan or vegetarian friendly. Collagen is the most abundant protein in the human body. pii: E1356. Collagen supplements have the potential to cause both headaches and migraines., According to a few case studies on using collagen to treat osteoarthritis, when participants were using the collagen supplement, they did report a lower pain level in their joints but among the most commonly reported side effects was a headache from time to time..