Eur Neurol 1992;32(1):44-51. "Water pills" can also decrease potassium levels. Moghadamnia, A. The effects of dietary licorice flavonoid oil supplementation on body balance control in healthy middle-aged and older Japanese women undergoing a physical exercise intervention: a randomized, double-blind, placebo-controlled trial. View abstract. Evid Based Complement Alternat Med 2016;2016:9852793. Licorice-induced hypermineralocorticoidism. Practitioners still sometimes suggest whole licorice for cough . 2001;21(7):501-503. Severe hypokalemic paralysis and rhabdomyolysis due to ingestion of liquorice. Ann Noninvasive Electrocardiol. Adjuvant role of a new emollient cream in patients with palmar and/or plantar psoriasis: a pilot randomized open-label study. Grapefruit juice and its flavonoids inhibit 11 beta-hydroxysteroid dehydrogenase. View abstract. View abstract. This information may not fit your specific health circumstances. J Clin Endocrinol Metab 1990;70(6):1637-1643. J Assoc Physicians India 1978;26(9):811-814. View abstract. 2008;9(3):88-98. Astragalus may be safe when used orally and appropriately. Luper, S. A review of plants used in the treatment of liver disease: part two. A randomized, double-blind comparison of licorice versus sugar-water gargle for prevention of postoperative sore throat and postextubation coughing. View abstract. View abstract. Int Immunopharmacol 2012;14(1):27-31. In Vivo 2021;35(4):2163-2169. Lancet 1990;335(8697):1060-3. View abstract. Yuan, H. N., Wang, C. Y., Sze, C. W., Tong, Y., Tan, Q. R., Feng, X. J., Liu, R. M., Zhang, J. Li C, Wang ZB. Practitioner 1973;210:820-3. View abstract. Beretta-Piccoli, C., Salvade, G., Crivelli, P. L., and Weidmann, P. Body-sodium and blood volume in a patient with licorice-induced hypertension. is tatcha violet c brightening serum safe for pregnancy is tatcha violet c brightening serum safe for pregnancy Because licorice has a hormone-like effect, it can relieve excessive gastric acid secretion. View abstract. 2004;4(3):377-386. Clinical application of compound Glycyrrhizin tablets in the treatment of patients with Simplex Henoch-Schonlein Purpura and its effect on immune function. Imtiaz, K. E. Sweet root, bitter pill: liquorice-induced hyperaldosteronism. View abstract. View abstract. BMJ Case Rep 2012;2012. Hasani-Ranjbar, S., Nayebi, N., Moradi, L., Mehri, A., Larijani, B., and Abdollahi, M. The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review. World J Gastroenterol 2005;11:2124-9. . Int Urol Nephrol. 2010 Nov;35(10):1587-93. Some sources claim that it's contraindicated during pregnancy . Previous studies have estimated that a dose of 1 to 5 grams (g) of licorice root daily is safe for most adults. Licorice (Glycyrrhizae Radix) 15 g: NR: Zhao (2016) [36] . Helpful. N Engl J Med 1999;341:1158. Reuter, J., Merfort, I., and Schempp, C. M. Botanicals in dermatology: an evidence-based review. Z., Zhang, Y. Scali, M., Pratesi, C., Zennaro, M. C., Zampollo, V., and Armanini, D. Pseudohyperaldosteronism from liquorice-containing laxatives. Yamada, K., Kanba, S., Yagi, G., and Asai, M. Effectiveness of herbal medicine (shakuyaku-kanzo-to) for neuroleptic-induced hyperprolactinemia. View abstract. Fan ZJ, Liu JM, Li XX, et al. The roots are commonly used in Traditional Chinese Medicine (TCM) for many purposes. Concomitant Use of High-dose Methotrexate and Glycyrrhizin Affects Pharmacokinetics of Methotrexate, Resulting in Hepatic Toxicity. Koo YK, Kim JM, Koo JY, et al. View abstract. 2000;19(8):434-439. 30. Pak J Med Sci 2022;38(1):271-275. The efficacy of an ayurvedic preparation of yashtimadhu (Glycyrrhiza glabra) on radiation-induced mucositis in head-and-neck cancer patients: A pilot study. View abstract. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Comparative Study of the Effect of Licorice Muco-adhesive Film on Radiotherapy Induced Oral Mucositis, A Randomized Controlled Clinical Trial. J Ethnopharmacol 2002;81:101-4.. View abstract. Taking licorice might reduce the effects of blood pressure medications. . Moreover, it will be necessary to check for recurrence . View abstract. van der Zwan A. Zhong.Xi.Yi.Jie.He.Za Zhi. Hum Exp Toxicol 2012;31(12):1295-1298. J Pharmacobiodyn 1983;6:153-60. . View abstract. Aoki, F., Nakagawa, K., Kitano, M., Ikematsu, H., Nakamura, K., Yokota, S., Tominaga, Y., Arai, N., and Mae, T. Clinical safety of licorice flavonoid oil (LFO) and pharmacokinetics of glabridin in healthy humans. Saeedi, M., Morteza-Semnani, K., and Ghoreishi, M. R. The treatment of atopic dermatitis with licorice gel. J Biol Response Mod 1985;4:551-84. View abstract. Neth J Med 2005;63:119-20. View abstract. They also have a range of other intriguing activities. 2020;247:112226. View abstract. Farese RV Jr, Biglieri EG, Shackleton CH, et al. Large amounts of licorice can decrease potassium levels in the body. Dellow EL, Unwin RJ, Honour JW. Lee YS, Lorenzo BJ, Koufis T, et al. View abstract. Phytother Res. Elinav E, Chajek-Shaul T. Licorice consumption causing severe hypokalemic paralysis. Int Endod.J 2011;44(1):51-58. J Telemed Telecare. I like herbal and fuit teas and a particular favourite of mine contains liquorice. Liu C, Wang J, Yang J. J Gastroenterol Hepatol 1999;14(11):1093-1099. Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats. View abstract. Holtmann G, Madisch A, Juergen H, et al. Hasegawa, J., Suyama, Y., Kinugawa, T., Morisawa, T., and Kishimoto, Y. Echocardiographic findings of the heart resembling dilated cardiomyopathy during hypokalemic myopathy due to licorice-induced pseudoaldosteronism. Biofactors 2009;35(1):98-104. One of its most known effects is the induction of hypertension, and it can induce what appears to be pseudohyperaldosteronism, due to glycyrrhetinic acid, the main active component of the root. Kuriyama A, Maeda H. Topical application of licorice for prevention of postoperative sore throat in adults: a systematic review and meta-analysis. View abstract. Intern Med 2017;56(2):175-9. View abstract. 2020;383(13):1263-1275. Costa, A., Moises, T. A., Cordero, T., Alves, C. R., and Marmirori, J. Gender may affect the action of garlic oil on plasma cholesterol and glucose levels of normal subjects. Effects of the Japanese herbal medicine "Sho-saiko-to" (TJ-9) on in vitro interleukin-10 production by peripheral blood mononuclear cells of patients with chronic hepatitis C. Hepatology 1997;25(6):1390-1397. Hum.Exp Toxicol. View abstract. 2016 Oct;39:314-319. doi: 10.1016/j.intimp.2016.08.006. J Clin Periodontol 1991;18(3):210-212. Armanini D, De Palo CB, Mattarello MJ, et al. OTHER NAME(S): Acide Glycyrrhizique, Acide Glycyrrhizinique, Alca. Zhong Yao Cai 2000;23:557-60. . Kwon S, Jin C, Cho SY, et al. Am.J Chin Med 2004;32(4):569-578. Lorenzin, F., Degen, C., Milani, A., Siciliano, M., and Rossi, L. [Pseudo-hyperaldosteronism caused by licorice. An evaluation of the efficacy of licorice gargle for attenuating postoperative sore throat: a prospective, randomized, single-blind study. [Application of dannang recipe no. Red Peony Root (Paeniae Rubra Radix) 8 g Myrrh (Myrrha) . View abstract. Liquorice and hypertension. A., Keller, W. J., Pereira, M. A., and Kinghorn, A. D. Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra). Advancing combination treatment with glycyrrhizin and boswellic acids for hospitalized patients with moderate COVID-19 infection: a randomized clinical trial. Postgrad Med J 1980;56(657):526-529. View abstract. 2020 Dec;58(1):352-356. Janse A, van Iersel M, Hoefnagels WH, Olde Rikker MG. Brayley J, Jones J. Life-threatening hypokalemia associated with excessive licorice ingestion (letter). Bernardi, M., D'Intino, P. E., Trevisani, F., Cantelli-Forti, G., Raggi, M. A., Turchetto, E., and Gasbarrini, G. Effects of prolonged ingestion of graded doses of licorice by healthy volunteers. Schleimer, R. P. Potential regulation of inflammation in the lung by local metabolism of hydrocortisone. Pakravan F, Salehabad NH, Karimi F, Isfahani MN. Melzer J, Rosch W, Reichling J, et al. View abstract. A systemic review and meta-analysis of the clinical efficacy and safety of total glucosides of peony combined with methotrexate in rheumatoid arthritis. Biol Pharm Bull 2007;30(11):2191-2195. Some believe it may also increase estrogen and prolactin levels in women, though more research is warranted. View abstract. Licorice root contains glycyrrhizin, which can cause side effects when eaten in large amounts. View abstract. Zhong.Xi.Yi.Jie.He.Za Zhi. But not everyone will have the side . Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182. Saw palmetto. Vestn.Dermatol.Venerol. View abstract. Lozenge-induced hypermineralcorticoid state--a unique case of licorice lozenges resulting in hypertension and hypokalemia. G Ital Dermatol Venereol 2010;145(6):789-792. Effect of orally administered shao-yao-gan-cao-tang (Shakuyaku-kanzo-to) on muscle cramps in maintenance hemodialysis patients: a preliminary study. Effect of preoperative licorice lozenges on incidence of postextubation cough and sore throat in smokers undergoing general anesthesia and endotracheal intubation. Phytother Res 2008;22(2):141-148. Paeonia lactiflora : Peony is another popular anti-androgenic herb. Am J Psychiatry 1994;151:617-8. Ultrastruct Pathol 1992;16(5):529-535. View abstract. View abstract. Licorice is believed to have anti-androgenic effects, meaning that it may be active to reduce testosterone levels. Russo S, Mastropasqua M, Mosetti MA, et al. View abstract. A dose of 800 milligrams (mg) or more of licorice root per day has been linked to low potassium levels. The anti-estrogenic action of beta-glycyrrhetinic acid. In my research, I found that like with any natural. 2017 Sep;31(9):1330-1340. The treatment of human cancer with agents prepared from bovine cartilage. Petramfar P, Hajari F, Yousefi G, Azadi S, Hamedi A. Efficacy of oral administration of licorice as an adjunct therapy on improving the symptoms of patients with Parkinson's disease, A randomized double blinded clinical trial. . Exp Med Surg 1969;27:411-20. J Dermatolog Treat 2003;14(3):153-157. View abstract. Licorice reduces body fat mass in obese men and women. Additional reporting by Meghan De Maria. View abstract. This can be severe. View abstract. View abstract. A botanical dietary supplement from white peony and licorice attenuates nonalcoholic fatty liver disease by modulating microbiota and reducing inflammation . Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions. The immediate effect of Shakuyaku-kanzo-to, traditional Japanese herbal medicine, for muscular cramps during maintenance hemodialysis. Warfarin is used to slow blood clotting. Lozano, P., Flores, D., Martinez, S., Artigues, I., Rimbau, E. M., and Gomez, F. Upper limb ischemia induced by chronic licorice ingestion. Ann Mtg Digestive Disease Week 1999 May. Cureus 2020;12(11):e11656. But I didn't take it long enough to see any change. Effects of chalcones isolated from licorice roots on leukotriene biosynthesis in human polymorphonuclear neutrophils. Maeda T, Shinozuka K, Baba K, et al. View abstract. Lancet 2000;355(9198):134-138. Hossain, M. S., Takimoto, H., Hamano, S., Yoshida, H., Ninomiya, T., Minamishima, Y., Kimura, G., and Nomoto, K. Protective effects of hochu-ekki-to, a Chinese traditional herbal medicine against murine cytomegalovirus infection. Zhonghua Yi Xue Za Zhi 1983;63:477-81. 2010;16(4):216-218. View abstract. OTHER NAME(S): Bai Shao, Chi Shao, Chinese Peony, Common Peony, C. Peony (Paeonia lactiflora) is an herb. A comparison of carbenoxolone sodium and deglycyrrhizinated liquorice in the treatment of gastric ulcer in the ambulant patient. Phytotherapy Research 1997;11:207-210. van Gelderen, C. E., Bijlsma, J. Tamir S, Eizenberg M, Somjen D, et al. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1991;11(4):199-202, 195. Balakrishnan, V., Pillai, M. V., Raveendran, P. M., and Nair, C. S. Deglycyrrhizinated liquorice in the treatment of chronic duodenal ulcer. Proanthocyanidins, flavonoids, tannins, polysaccharides, and paeoniflorin are all considered to contribute to the medicinal activity of various forms of peony. Little is known about whether it's safe to use licorice root while breastfeeding. Clin Ter 1990;132(1):55-58. A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of a Mouthwash Containing Glycyrrhiza uralensis Extract for Preventing Dental Caries. [Treatment of refractory polycystic ovary syndrome by bushen huoxue method combined with ultrasound-guided follicle aspiration]. It has an effect similar to aldosterone. View abstract. Anesth Analg 2009;109(1):77-81. Fatal hypokalaemic alkalosis with tetany during liquorice and P.A.S. Korri, H., Awada, A., Baajour, W., Beaini, M., and Nasreddine, W. [Rapidly progressing quadriparesis secondary to licorice (souss) intoxication]. View abstract. View abstract. WebMD does not provide medical advice, diagnosis or treatment. View abstract. Be sure to have your blood checked regularly. Lapi F, Gallo E, Bernasconi S, et al. Lancet 2-10-1979;1(8111):319. View abstract. View abstract. It shows a wide range of biological and pharmacological activities, including anti-inflammatory and immune regulatory actions. Chinese herbal medicine for atopic eczema. B., and Zhang, Z. J. Zhou, Y., Huang, Z., and Huang, T. [Clinical study of shengxue mixture in treating aplastic anemia]. J Intern Med 1999;245:307-10. Lipids Health Dis 2011;10:29. Guo, D., Ye, G., and Guo, H. A new phenolic glycoside from Paeonia lactiflora. Therapeutic basis of glycyrrhizin on chronic hepatitis B. Antiviral Res 1996;30:171-7. Licorice might decrease how quickly the body breaks down methotrexate. Nephron 2002;90:240. J Nutr Sci Vitaminol. MacKenzie, M. A., Hoefnagels, W. H., Jansen, R. W., Benraad, T. J., and Kloppenborg, P. W. The influence of glycyrrhetinic acid on plasma cortisol and cortisone in healthy young volunteers. J Hum Hypertens 1995;9:345-8. A., van Dokkum, W., and Savelkoul, T. J. Glycyrrhizic acid: the assessment of a no effect level. Rees, W. D., Rhodes, J., Wright, J. E., Stamford, L. F., and Bennett, A. Kase Y, Saitoh K, Ishige A, et al. Medicinal uses of licorice through the millennia: the good and plenty of it. View abstract. View abstract. This versatile anti-inflammatory plant can benefit digestive issues, hormone health, and skin health as well as helping ease problems with menstruation and menopause. Antiviral Res 1987;7(3):127-137. View abstract. Ohta H, Ni JW, Matsumoto K, et al. However, when Angelica Sinensis was tested in combination with products containing other substances, its activity was reduced. 2017 Apr 1;27(2):150-154. doi: 10.1684/ejd.2016.2946. Double-blind, placebo-controlled, randomized, pilot clinical trial of ImmunoGuard--a standardized fixed combination of Andrographis paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra chinensis Bail. Liu J. Eur J Drug Metab Pharmacokinet. Chen, W. G. and Ba, Z. M. Prof. ZHANG Yi's experience in treating severe arrhythmia. J Clin Pharm Ther 2001;26:271-8. View abstract. The 1:1 of peony and licorice group can significantly reduced the ureteral smooth muscle tension and Christina Loosestrife herb can increase the u reteral tension, but the amount is too large, the mechanism may be related with the diuretic row stone. Badr, A. E., Omar, N., and Badria, F. A. 2014 Jun;23(3):189-92. View abstract. Crit Care 2011;15(1):R64. Chem Pharm Bull (Tokyo) 1994;42(5):1056-1062. View abstract. In 1977, researchers reported the case of a 58-year-old woman who was eating a whopping 1.8 kilograms (about 63.5 ounces) of black licorice per week and went into cardiac arrest. Not too many side effects of peony tea that we need to worry about. Wu, T. H., Chiu, T. Y., Tsai, J. S., Chen, C. Y., Chen, L. C., and Yang, L. L. Effectiveness of Taiwanese traditional herbal diet for pain management in terminal cancer patients. Coloclyster of Red Peony Root Granules Alleviates Moderately Severe Acute Pancreatitis: A Double-Blinded, Placebo-Controlled, Randomized Clinical Trial. Peters, M. C., Tallman, J. Acharya SK, Dasarathy S, Tandon A, et al. Effects of low-dose liquorice alone or in combination with hydrochlorothiazide on the plasma potassium in healthy volunteers. Ned.Tijdschr Geneeskd. Liang, R., Chen, M. R., and Xu, X. Licorice can be used orally with Peony to treat women with Polycystic Ovary Syndrom to increase fertility; it can also treat patients with abnormal Prolactin, muscle spasms, or to reduce the pain of cancer. View abstract. View abstract. A preliminary open trial on interferon stimulator (SNMC) derived from Glycyrrhiza glabra in the treatment of subacute hepatic failure. Patients received either bromocriptine 5 mg daily for 4 weeks followed by 4 weeks of 22.5 grams daily of the peony-licorice decoction (equivalent to 25 mg of glycyrrhetinic acid), or the same drugs in the reverse order. A newly-filed federal lawsuit claims eating too much of The Hershey Company's Good & Plenty and black licorice Twizzlers candies can cause serious health problems, maybe even death. Chinese peony root comes in two different forms. Fung AY, Look PC, Chong LY, et al. Chewing tobacco flavored with Licorice may cause serious side effects such as high blood pressure. Effects of glycyrrhizin on the pharmacokinetics of nobiletin in rats and its potential mechanism. View abstract. Am J Chin Med 1992;20(3-4):313-317. Epilepsy Res 2021;176:106735. [Comparison of pre- and post-treatmental hepatohistology with heavy dosage of Paeonia rubra on chronic active hepatitis caused liver fibrosis]. View abstract. Zhongguo Zhong.Yao Za Zhi 2009;34(21):2695-2700. Br J Clin Pharmacol 2008;66:572-4. We could use compounds in these foods to . For people who already have high blood pressure or heart or kidney disease, as little as 5 g/day can cause these side effects. Gupta D, Agrawal S, Sharma JP. Chatterjee, N., Domoto-Reilly, K., Fecci, P. E., Schwamm, L. H., and Singhal, A. Mamgain RK, Gupta M, Mamgain P, et al. View abstract. Oh, G. S., Pae, H. O., Choi, B. M., Jeong, S., Oh, H., Oh, C. S., Rho, Y. D., Kim, D. H., Shin, M. K., and Chung, H. T. Inhibitory effects of the root cortex of Paeonia suffruticosa on interleukin-8 and macrophage chemoattractant protein-1 secretions in U937 cells. J Nutr 2001;131:1471-8. Bannister, B., Ginsburg, R., and Shneerson, J. Cardiac arrest due to liquoriceinduced hypokalaemia. Serra, A., Uehlinger, D. E., Ferrari, P., Dick, B., Frey, B. M., Frey, F. J., and Vogt, B. Glycyrrhetinic Acid decreases plasma potassium concentrations in patients with anuria. Fiore, C., Eisenhut, M., Krausse, R., Ragazzi, E., Pellati, D., Armanini, D., and Bielenberg, J. Antiviral effects of Glycyrrhiza species. Bisogni V, Rossi GP, Cal LA. View abstract. Ruiz-Granados, E. S., Shouls, G., Sainsbury, C., and Antonios, T. A salty cause of severe hypertension. J Contemp Dent Pract 2010;11(1):E088-E094. Allergic contact dermatitis to Glycyrrhiza inflata root extract in an anti-acne cosmetic product. Yang DG. A pilot study. Leem, K., Kim, H., Boo, Y., Lee, H. S., Kim, J. S., Yoo, Y. C., Ahn, H. J., Park, H. J., Seo, J. C., Kim, H. K., Jin, S. Y., Park, H. K., Chung, J. H., and Cho, J. J. Pharmacotherapeutic effects of toki-shakuyaku-san on leukorrhagia in young women. Goto, F., Asama, Y., and Ogawa, K. Sho-saiko-to-ka-kikyo-sekko as an alternative treatment for chronic tonsillitis to avoid surgery. Li J, Fan X, Wang Q. Hypertensive crisis with 2 target organ impairment induced by glycyrrhizin: a case report. View abstract. Nippon Rinsho 1994;52:1817-22. The inhibition of phenylhydroquinone-induced oxidative DNA cleavage by constituents of Moutan Cortex and Paeoniae Radix. . Another type of licorice, called DGL or deglycyrrhizinated licorice, does not seem to have the same side effects and is sometimes used to treat peptic ulcers, canker sores, and reflux (GERD). View abstract. View abstract. Murck H, Lehr L, Hahn J, Braunisch MC, Jezova D, Zavorotnyy M. Adjunct Therapy With Glycyrrhiza Glabra Rapidly Improves Outcome in Depression-A Pilot Study to Support 11-Beta-Hydroxysteroid Dehydrogenase Type 2 Inhibition as a New Target. Life Sci 2-23-2001;68(14):1687-1694. van Rossum, T. G., Vulto, A. G., Hop, W. C., and Schalm, S. W. Pharmacokinetics of intravenous glycyrrhizin after single and multiple doses in patients with chronic hepatitis C infection. Licorice is available in many different types of products, including candies, lozenges, teas, chewing, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, Side effects in people after breathing tube removal. Zhong Xi Yi Jie He Za Zhi 1991;11:102-4, 69. Wilson, J. View abstract. Peony might have some of the same effects as estrogen. WebMD does not provide medical advice, diagnosis or treatment. Tewari SN, Wilson AK. J Clin Anesth 2019;54:25-32. Wang H, Wei W, Wang NP, et al. Eur J Obstet Gynecol.Reprod Biol 2007;131(1):61-67. Side effects, toxicity, and interactions. The biological compound pesticide is manufactured from the raw materials of Ailanthus altissima Swingle, Cyrtomium fortunei, geranium wilfordii, fructus forsythiae, Scutellaria baicalensis, gallnut, areca-nut, coconut shell, radix sophorae . Contact Dermatitis 2008;59(1):52. [Peony tincture in the complex treatment of allergic dermatoses]. Hukkanen J, Ukkola O, Savolainen MJ. 2018;38(2):617-8. Arase, Y., Ikeda, K., Murashima, N., Chayama, K., Tsubota, A., Koida, I., Suzuki, Y., Saitoh, S., Kobayashi, M., and Kumada, H. The long term efficacy of glycyrrhizin in chronic hepatitis C patients. Cooper, H., Bhattacharya, B., Verma, V., McCulloch, A. J., Smellie, W. S., and Heald, A. H. Liquorice and soy sauce, a life-saving concoction in a patient with Addison's disease. Results of a double-blind placebo controlled comparative study]. Further studies on the mechanism of the mineralocorticoid action of licorice in humans. [RETRACTED]. Paeoniflorin, a constituent of white peony root, has demonstrated inhibition of testosterone synthesis in vitro, without affecting estradiol synthesis.It reduces testosterone production by the ovaries but not the adrenal glands. 2020;50:102401. American Herbal Products Association's Botanical Safety Handbook, Second Edition. Licorice. Li G, Simmler C, Chen L, et al. Nussbaumer, U., Landolt, M., Rothlisberger, G., Akovbiantz, A., Keller, H., Weber, E., Blum, A. L., and Peter, P. [Postoperative stress hemorrhage: ineffective prevention with pepsin inhibitor and deglycyrrhizinized licorice extract.