1990;12(4):28-33. 1996;41(6):543-549. If youre suffering from bone or prostate cancer, radioactive strontium therapyshould only be given by or under the direct supervision of a doctor with specialized training in nuclear medicine or radiation oncology. Physio Flex Pro - Editor's Choice. Since strontium is denser than calcium, it is difficult to assess actual bone improvement in a DXA scan. Hughes, N., Mason, S., Jeffery, P., Welton, H., Tobin, M., O'Shea, C., and Browne, M. A comparative clinical study investigating the efficacy of a test dentifrice containing 8% strontium acetate and 1040 ppm sodium fluoride versus a marketed control dentifrice containing 8% arginine, calcium carbonate, and 1450 ppm sodium monofluorophosphate in reducing dentinal hypersensitivity. Supplements are increasingly available over the counter and through the Internet. Osteoporos.Int. Good luck to all of you. The next big and interesting use of this alkaline earth metal was when it was used in the television production industry, specifically in the cathode ray tubes of color televisions. Blotman, F., Maheu, E., Wulwik, A., Caspard, H., and Lopez, A. Efficacy and safety of avocado/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip. 5 Possible (and Controversial) Health Benefits, The Foods, Supplements & Oils to Increase Bone Healing, Daniel Fast: Benefits for Your Spiritual, Emotional and Physical Health, 15 Fermented Foods for a Healthy Gut and Overall Health, 9 Proven Black Seed Oil Benefits that Boost Your Health, L-Glutamine Benefits Leaky Gut & Metabolism, Chia Seeds Benefits: The Omega-3, Protein-Packed Superfood, Apple Cider Vinegar Benefits for Weight Loss, Skin Health, Cholesterol & More. Hello @bonelady. 2008;9:165. Fidelix, T. S., Soares, B. G., and Trevisani, V. F. Diacerein for osteoarthritis. Even though its not considered a nutrient, its known that the human body can absorb strontium and utilize it as it would calcium. They. 2013 Feb;72(2):179-86. doi: 10.1136/annrheumdis-2012-202231. Marie PJ, Ammann P, Boivin G, Rey C. Mechanisms of action and therapeutic potential of strontium in bone. View abstract. Osteoporos.Int. The Earths crust also has Sr at an estimated average of 360 parts per million. My teeth are really strong and it feels like my bones are too. A prescription form of strontiumstrontium ranelate (the ranelate salt), known as Protelos/Osseor was authorized in the European Union to treat severe osteoporosis in women who have been through the menopause and men who are at high risk of broken bones or fracture in the spine and the hip. Description Pure Encapsulations' Strontium capsules provide one of the many trace minerals essential to bone health. This is more important for postmenopausal women. 2015 Feb;74(2):422-9. doi: 10.1136/annrheumdis-2013-203989. N Engl J Med 2004;350:504-6. Note that the numbers in parentheses (1, 2, etc.) Osteoporos.Int. Basically, it is like you are consuming rocks. J.Fam.Pract. 2016 Jan;27(1):211-8. doi: 10.1007/s00198-015-3266-z. Reginster JY, Badurski J, Bellamy N, Bensen W, Chapurlat R, Chevalier X, Christiansen C, Genant H, Navarro F, Nasonov E, Sambrook PN, Spector TD, Cooper C. Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial. It may even cause constipation or digestive discomfort. 2006;(2):CD005321. Stable strontiums atomic symbol is Sr, its atomic number is 38 and its atomic weight is 87.62. Johnson, G. H., Bales, D. J., Gordon, G. E., and Powell, L. V. Clinical performance of posterior composite resin restorations. Kidney Int 1999;56:1886-92. View abstract. CMAJ. Strontium has a long list of undesirable side-effects, commonly ranging from nausea to skin irritation, and less often (fortunately), blood clots and fainting. Positive impact of compliance to strontium ranelate on the risk of nonvertebral osteoporotic fractures. View abstract. Effects of oral supplementation with stable strontium. A., Korotkova, T. A., Toroptsova, N. V., Smirnov, A. V., Demin, N. V., Rodionova, S. S., Buklemeshev, IuV, and Shumskii, A. Gutteridge DH, Robinson CJ, Joplin GF. Faith123 may", "Hello @bonelady -- welcome to Connect. B., Gamble, G. D., and Reid, I. R. Effect of osteoporosis treatment on mortality: a meta-analysis. It is a member of the aragonite group. (4b) Another mineral containing strontium iscelestite, which is used in strontium metal alloys. Medi-Physics, Inc., Amersham Healthcare, Arlington Heights, IL, 1998. https://www.cancerpaintherapy.com/METATECHPAGE.htm. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. 1972;43(6):367-372. It seems to play a role in how your body makes new bone while it slows the breakdown of old bone. View abstract. Research from Europe suggests that patients on strontium ranelate may have an increased risk of heart attacks. 1994;65(2):113-119. View abstract. IT was a 9 year nightmare until I started the strontium citrate. This is not the same as making new bone. 1990;1(1):19-23. View abstract. Faith123 may be able to answer a question or two of yours about the reclast infusion treatment and her experience with it. View abstract. (24, 25). View abstract. Rev Rhum Engl Ed 1997;64(12):825-834. Sr can be found in Group 2 of the periodic table. JAMA 10-13-1999;282(14):1344-1352. Osteoporos Int. Adouble-blind, parallel, comparative study study published back in 1987 in the Journal of Periodontology looked at the effects of a toothpaste containing10 percent strontium chloride hexahydrateon 61 subjects with hypersensitivity. View abstract. Radiat.Environ.Biophys. Zhai, H., Hannon, W., Hahn, G. S., Pelosi, A., Harper, R. A., and Maibach, H. I. Strontium nitrate suppresses chemically-induced sensory irritation in humans. View abstract. Addy, M., Mostafa, P., and Newcombe, R. G. Effect of plaque of five toothpastes used in the treatment of dentin hypersensitivity. (12). I am actively and urgently in the process of deciding which osteoporosis treatment I want to "pitch" to my doctors. View abstract. How Well are You Living With Ankylosing Spondylitis? Arthritis Rheum 2007;56(7):2267-2277. Cochrane Musculoskeletal Group. Clin.Prev.Dent. I was diagnosed with osteopenia a little over a year ago but have not done anything other than trying to add more calcium rich food to my diet. A 2007 study only involved six participants, but the researchers found thatregular toothbrushing with a strontium-supplemented toothpaste has been found to increase the strontium content in the exposed enamel, which can be an advantage in the prevention of cariogenesis. (15) What is cariogenesis? 2005;7(3):R625-R633. Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others. A coordinator will follow up to see if Mayo Clinic is right for you. 1999;25(9):689-694. View abstract. Currently, we do not have a way to measure the false increase in bone density that results when you take a supplement or a medication that includes strontium.. View abstract. Nonvertebral fracture benefit from oral ibandronate administered daily or with a unique drug-free interval: Results from a pivotal phase III study in postmenopausal osteoporosis (PMO). (. Human biokinetics of strontium--part II: Final data evaluation of intestinal absorption and urinary excretion of strontium in human subjects after stable tracer administration. Towheed TE, Maxwell L, Anastassiades TP, et al. Strontium is a trace mineral that may help keep bones strong by preventing bone loss and promoting bone growth. 2004;86-A(3):538-545. Cheung, K. M., Lu, W. W., Luk, K. D., Wong, C. T., Chan, D., Shen, J. X., Qiu, G. X., Zheng, Z. M., Li, C. H., Liu, S. L., Chan, W. K., and Leong, J. C. Vertebroplasty by use of a strontium-containing bioactive bone cement. It's not known if strontium contained in dietary supplements has these effects. Anastasilakis, A. D., Polyzos, S. A., Avramidis, A., Papatheodorou, A., and Terpos, E. Effect of strontium ranelate on lumbar spine bone mineral density in women with established osteoporosis previously treated with teriparatide. View abstract. View abstract. The efficacy of glucosamine sulfate in osteoarthritis: financial and nonfinancial conflict of interest. Strontium is similar to calcium. That means it may affect how strong your bones are. J.Dent.Res. Aluminum, iron, lead, cadmium, copper, zinc, chromium, magnesium, strontium, and calcium content in bone of end-stage renal failure patients. Go to the Bones, Joints & Muscles Support Group. 2007;357:nihpa40967. Osteoporos Int. Please note the date of the last review on all articles. View abstract. (1) A radioactive form is even used as a form of cancer treatment for bone cancers andprostate cancer. Taking strontium with quinolones might decrease their effectiveness. (Accessed 10 October 2006). Liu, J. M., Wai-Chee, Kung A., Pheng, C. S., Zhu, H. M., Zhang, Z. L., Wu, Y. Y., Xu, L., Meng, X. W., Huang, M. L., Chung, L. P., Hussain, N. H., Sufian, S. S., and Chen, J. L. Efficacy and safety of 2 g/day of strontium ranelate in Asian women with postmenopausal osteoporosis. Tofu, firm, made with calcium sulfate, cup 253 mg per serving. In addition, strontium ranelate isstopped if a patient develops heart or circulatory problems during the course of treatment. 2008;23(3):433-438. [4] Simpson, Lani. Brand: Algaecal. J.Periodontol. 2012. View abstract. El-Hajj Fuleihan G. Strontium ranelate--a novel therapy for osteoporosis or a permutation of the same? Strontium can be found in supplement form online and in health stores. What Is Secondary Prevention of Osteoporosis? Rabenda, V. and Reginster, J. Y. 2005;54(9):758-767. Rozhinskaia, L. I., Arapova, S. D., Dzeranova, L. K., Molitvoslovova, N. N., Marova, E. I., Il'in, A. V., Benevolenskaia, L. I., Nikitinskaia, O. Am on third brand of Strontium Citrate and doing better than on the first two. (4a) In addition, strontianite is a mineral that comes from concentrations of strontium compounds, and there are several strontium compounds. View abstract. View abstract. View abstract. Do not take it within 2 hours of ingesting calcium so I take it at bedtime. View abstract. Get answers to some of the most common questions about osteoporosis treatment. Strontium is a mineral found in seawater and soil. Ardissino G, Schmitt CP, Bianchi ML, et al. Pearce, E. I. and Sissons, C. H. The concomitant deposition of strontium and fluoride in dental plaque. Neer, R. M., Arnaud, C. D., Zanchetta, J. R., Prince, R., Gaich, G. A., Reginster, J. Y., Hodsman, A. Results 12 weeks following cessation of 8 weeks' supervised use. (10), Radioactive strontium-89 is given intravenously for advanced bone cancer or cancer that has spread to the bones such as metastatic prostrate cancer. The most common supplement form is strontium citrate. WebMD does not provide medical advice, diagnosis or treatment. With a few simple measures, the application of Sr-89 causes no problems. Molybdenum, nickel, cobalt, vanadium, and strontium in total diets. Dose-dependent effects of strontium on osteoblast function and mineralization. After you stop taking any of these bone-building medications, you generally will need to take another osteoporosis drug to maintain the new bone growth. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. Rizzoli, R., Laroche, M., Krieg, M. A., Frieling, I., Thomas, T., Delmas, P., and Felsenberg, D. Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis. Thromb.Haemost. (Accessed 13 March 2004). J.Dent. Note that the numbers in parentheses (1, 2, etc.) Dahl SG, Allain P, Marie PJ, et al. Its also referred to as being a soft metal like lead. Boron is an element. View abstract. 4-12-2005;172(8):1039-1043. After a 7-day . J Periodontol. Black, D. M., Cummings, S. R., Karpf, D. B., Cauley, J. Strontium ranelate discontinued. New treatment strategies: ipriflavone, strontium, vitamin D metabolites and analogs. View abstract. J Rheumatol 2000;27:205-11. Lyles, K. W., Colon-Emeric, C. S., Magaziner, J. S., Adachi, J. D., Pieper, C. F., Mautalen, C., Hyldstrup, L., Recknor, C., Nordsletten, L., Moore, K. A., Lavecchia, C., Zhang, J., Mesenbrink, P., Hodgson, P. K., Abrams, K., Orloff, J. J., Horowitz, Z., Eriksen, E. F., and Boonen, S. Zoledronic Acid in Reducing Clinical Fracture and Mortality after Hip Fracture. I have had reclast infusions for six years for osteoporosis. J.Dent.Res. Mazor, Z., Brayer, L., Friedman, M., and Steinberg, D. Topical varnish containing strontium in a sustained-release device as treatment for dentin hypersensitivity. View abstract. and I don't hear much about it. An extensive scientific review published in 2000 concludes that: It is clear from published reports and from daily practice that injection with Sr-89 is a simple, well-tolerated treatment providing a considerable chance of good palliation of pain in patients with bone metastases from prostate cancer. It is prescribed only for those who would otherwise have no other suitable treatment to reduce their risk of broken bones.[2]. Injecting myself daily. N.Engl.J.Med. 2006;55(8):669-675. 2009;41(7):559-562. (Strontium may remain in the bones for as long as 710 years after the last dose.) 2006;(1):CD005117. Connect with thousands of patients and caregivers for support, practical information, and answers. Reginster, J. Y. and Meunier, P. J. Strontium ranelate phase 2 dose-ranging studies: PREVOS and STRATOS studies. View abstract. McAlindon TE, LaValley MP, Gulin JP, Felson DT. Olson, B. L., McDonald, J. L., Jr., and Stookey, G. K. The effect of strontium and fluoride upon in vitro plaque and rat caries. Severe allergic reactions to magnesium oxide are rare. Expert.Opin.Investig.Drugs 2004;13(7):857-864. Bone metastases can be extremely painful. Arrich, J., Piribauer, F., Mad, P., Schmid, D., Klaushofer, K., and Mullner, M. Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis. The possible risks of strontium warrant more long-term independent studies. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. Uchida, A., Wakano, Y., Fukuyama, O., Miki, T., Iwayama, Y., and Okada, H. Controlled clinical evaluation of a 10% strontium chloride dentifrice in treatment of dentin hypersensitivity following periodontal surgery. Bone. This decreases the amount of tetracyclines that can be absorbed. My fear is the cost. Omdahl JL, DeLuca HF. View abstract. Accessed May 1, 2018. Do not take it within 2 hours of ingesting calcium so I take it at bedtime. Calcif Tissue Int 2001;69:121-9. . Theres not enough research to know if strontium fights osteoporosis. (6), Strontium ranelate is a form that is sold as a prescription medication for osteoporosis and bone fractures in Europe and Australia. Clin Nucl Med 2004;29:81-5. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. Lo, G. H., LaValley, M., McAlindon, T., and Felson, D. T. Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis. Arch.Intern.Med. Les Laboratoires Servier, 2006. Strontium can attach to some antibiotics called quinolones in the stomach. View abstract. J.Bone Miner.Res. View abstract. View abstract. Kobler, A., Kub, O., Schaller, H. G., and Gernhardt, C. R. Clinical effectiveness of a strontium chloride- containing desensitizing agent over 6 months: a randomized, double-blind, placebo-controlled study. A comparison of the palliative effects of strontium-89 and external beam radiotherapy in metastatic prostate cancer. Given that strontium test results are tied to the strontium ion, citrate is your best option to reap its bone-building benefits. Initially Forteo was top contender (refrigeration requirement is an issue) until I came across Tymlos (refrigeration being easier to manage is one of several benefits over Forteo). D'Haese PC, Couttenye MM, Lamberts LV, et al. Performance Lab Flex - Best For Athletes. Many consumers are being lured by the advertised benefits of strontium for bone health. Collins, J. F. and Perkins, L. Clinical evaluation of the effectiveness of three dentifrices in relieving dentin sensitivity. O'Donnell, S., Cranney, A., Wells, G. A., Adachi, J. D., and Reginster, J. Y. Strontium ranelate for preventing and treating postmenopausal osteoporosis. Medications That Can Be Bad for Your Bones, Tests to Determine Secondary Causes of Bone Loss, American Bone Health and Susan G. Komen Team Up for Healthy Living Campaign, How cancer patients can lower the risk of bisphosphonate-related osteonecrosis of the jaw (BRONJ), What we know about vitamin D and bone health, American Bone Health calls on Americans to know their risk factors and take action to prevent falls and broken bones during Falls Prevention Awareness Week, Understanding How Obesity Affects Bone Health and Risk of Fractures, American Bone Health calls on American to Build Better Bones during National Osteoporosis Month 2022, Taking strontium supplements for any period of time is likely to make future bone density tests inaccurate. It is given as an injection every month at your doctor's office and is limited to one year of treatment. View abstract. No difference in intestinal strontium absorption after oral or IV calcitriol in children with secondary hyperparathyroidism. 2007;19(4):330-333. View abstract. View abstract. . They won't do any studies but the END OF FRACTURES SAYS IT ALL! Calcium and strontium metabolic studies in patients on CAPD. View abstract. If side effects are persistent or worsen, it is best to talk to your healthcare provider. N.Engl.J.Med. J.Bone Miner.Res. A., Christiansen, S. C., Romundstad, P., Cannegieter, S. C., Rosendaal, F. R., and Hammerstrom, J. Increased serum strontium levels in dialysis patients: an epidemiological survey. 2002;17(3):449-454. J Periodontol 1987;58:470-4. Do not be misled by marketing materials that compare them to strontium ranelate. Causes, symptoms, risk factors, and treatment. 2004;5(7):1635-1638. Oral Dis. Also, the FDA doesnt regulate supplements in the same way as prescription drugs, so it's not possible to know if if they are safe or work well or even how much of the main ingredient they contain. 2010;46(4):1038-1042. doi: 10.1016/j.bone.2009.12.006. J Clin Endocrinol Metab 2002;87:2060-6.. View abstract. J.Periodontol. Arch.Intern.Med. 1986;12(9):447-454. Strontium is an element that has been shown to improve bone healing. Various tests for tooth sensitivity by the researchers revealed that compared to the placebo, the toothpaste containing Sr decreased dentinal hypersensitivity to a significantly greater degree. Positive results were seen within two weeks and continued for the 12 week length of the study. No difference in intestinal strontium absorption after an oral or an intravenous 1,25(OH)2D3 bolus in normal subjects. JAMA 12-17-2003;290(23):3115-3121. View abstract. For two years, 174 of the men received 2 grams of strontium ranelate per day while 87 men received a placebo. Papoiu AD, Valdes-Rodriguez R, Nattkemper LA, Chan YH, Hahn GS, Yosipovitch G. A novel topical formulation containing strontium chloride significantly reduces the intensity and duration of cowhage-induced itch. JAMA 12-23-1998;280(24):2077-2082. Ringe, J. D. and Doherty, J. G. Absolute risk reduction in osteoporosis: assessing treatment efficacy by number needed to treat. 23(1):305-315. doi: 10.1007/s00198-011-1758-z. The forms of strontium available over-the-counter in the U.S. or on the Internet are usually strontium citrate or strontium chloride. Schrooten I, Elseviers MM, Lamberts LV, et al. Salmon, pink, canned, solids with bone, 3 ounces 181 mg per serving. J.Am.Dent.Assoc. Osteoporos.Int. McClung, M. R., Geusens, P., Miller, P. D., Zippel, H., Bensen, W. G., Roux, C., Adami, S., Fogelman, I., Diamond, T., Eastell, R., Meunier, P. J., and Reginster, J. Y. View abstract. Apostolidis N, Paradellis T, Karydas A, et al. O'Donnell S, Cranney A, Wells GA, et al. Chesnut, C. H., III, Silverman, S., Andriano, K., Genant, H., Gimona, A., Harris, S., Kiel, D., LeBoff, M., Maricic, M., Miller, P., Moniz, C., Peacock, M., Richardson, P., Watts, N., and Baylink, D. A randomized trial of nasal spray salmon calcitonin in postmenopausal women with established osteoporosis: the prevent recurrence of osteoporotic fractures study. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. The radioactive form of Sr is not available as a dietary supplement, but it is considered to likely be safe when administered by a health care professional by IV. The Alendronate Phase III Osteoporosis Treatment Study Group. Nephrol.Dial.Transplant. 2000;75(1-3):253-263. Some years later in 1808, it was was isolated in its metallic formusing electrolysisby Sir Humphry Davy at the Royal Institution in London. The effect of a strontiumhloridetoothpaste on root hypersensitivity in a controlled clinical study. Arch Intern Med 2003;163:1514-22. View abstract. This is the newest bone-building medication to treat osteoporosis. It has shown only a modest effect in preventing recurrent vertebral fractures. Effects of strontium ranelate on spinal osteoarthritis progression. View abstract. View abstract. Arthritis Rheum 1998;41:81-91. The PRAC weighed the benefits of the medicine against the known risks and concluded that the balance was no longer favourable and recommended Protelos/Osseor be suspended until there are new data showing a favourable balance in a defined patient group.[1]. J.Periodontol. Some male hormones include testosterone, nandrolone, oxandrolone, and oxymetholone. Is Lamb Healthy? It's also known to increase osteoprotegerin that serves as the decoy for the RANKL and slows the rate of bone resorption. View abstract. In nature, it is found in highest amounts in the ocean and consequently in certain bony fish. J.Periodontol. Bruyere, O., Burlet, N., Delmas, P. D., Rizzoli, R., Cooper, C., and Reginster, J. Y. Liberman, U. Spector, T. D., Conaghan, P. G., Buckland-Wright, J. C., Garnero, P., Cline, G. A., Beary, J. F., Valent, D. J., and Meyer, J. M. Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]. Further studies are warranted to determine which radiopharmaceutical is preferred for pain relief and/or improvement of survival. It does not recommend it as a treatment for anyonewho has or has had heart or circulatory problems such as stroke, heart attack, or obstruction of the blood flow in the arteries. Obtaining strontium from your diet by eating seafood, whole grains,beans, spinach, lettuce, celery, androot vegetableslike carrots and potatoes is the safest way to boost your strontium levels. Gillam, D. G., Newman, H. N., Bulman, J. S., and Davies, E. H. Dentifrice abrasivity and cervical dentinal hypersensitivity. Due to mixed research findings, its very important to speak with your doctor before supplementing with strontium to treat any health concern especially if you have Pagets disease of bone, kidney problems or any blood clotting disorders. Bianchi ML, Ardissino GL, Schmitt CP, et al. It can be found in soil and seawater, and its actually used as a supplemental treatment for osteoporosis and other bone diseases. View abstract. Strontium is a mineral and alkaline earth metal like calcium, and it seems to work similarly to calcium in the body with its main benefit being a boost to bone health. A common therapeutic dose you will often seen recommended for boosting bone health is 680 milligrams per day. View abstract. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Bruyere, O., Roux, C., Detilleux, J., Slosman, D. O., Spector, T. D., Fardellone, P., Brixen, K., Devogelaer, J. P., Diaz-Curiel, M., Albanese, C., Kaufman, J. M., Pors-Nielsen, S., and Reginster, J. Y. Gedalia, I., Brayer, L., Kalter, N., Richter, M., and Stabholz, A. Wang, C. T., Lin, J., Chang, C. J., Lin, Y. T., and Hou, S. M. Therapeutic effects of hyaluronic acid on osteoarthritis of the knee. Arch Dis Child 1996;75:524-6. Ann.Rheum.Dis. Calcif Tissue Int 2000;67:122-7. Bingham, C. O., III, Buckland-Wright, J. C., Garnero, P., Cohen, S. B., Dougados, M., Adami, S., Clauw, D. J., Spector, T. D., Pelletier, J. P., Raynauld, J. P., Strand, V., Simon, L. S., Meyer, J. M., Cline, G. A., and Beary, J. F. Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study. Symptoms modifying effect of avocado/soybean unsaponifiables (ASU) in knee osteoarthritis. A., Mohr, D. N., Petterson, T. M., O'Fallon, W. M., and Melton, L. J., III.