Nutrition Business Journal. No. Am J Clin Nutr 2010;91:1268-1272. Your child needs a variety of vitamins and minerals to grow healthy and strong. Choosing whole grain side dishes, cereals, breads and more may lower the risk for heart disease, type 2 diabetes and cancer and improve digestion, too. Investigators who followed a multiethnic cohort of 182,099 men and women aged 4575 years living in Hawaii and California for an average 11 years found similar results [36]. Any mention in this publication of a specific product or service, or recommendation from an organization or professional society, does not represent an endorsement by ODS of that product, service, or expert advice. The greatest improvements in intake were for vitamins A and E and zinc. Breast Cancer Res Treat 2013;141:495-505. RCTs Nutrition 2017;36:60-6. Studies that have examined associations of MVMs with CVD risk include the Physicians Health Study I. Use of MVs or MVMs (not further defined) was associated with an 11% lower risk of colon cancer mortality than among nonusers. Adults in this age group might not be able to absorb enough of the protein-bound, naturally occurring vitamin B12 in food because gastric acidity tends to decline and atrophic gastritis tends to become more common with age [6]. JAMA 2012;308:1751-60. Vitamin C is responsible for synthesizing collagen and is necessary for proper wound healing.6 Vitamin C is also secreted in breast milk thus, a higher dietary intake is recommended for lactating women to make up for this loss. [, Larsson SC, kesson A, Bergkvist L, Wolk A. Multivitamin use and breast cancer incidence in a prospective cohort of Swedish women. Use of MVs and MVMs (products containing three or more vitamins and/or minerals in amounts below the ULs and no herbs) did not reduce the risk of any chronic disease. Mechanism of Action Exerts oncotic pressure, which expands volume of circulating blood and maintains cardiac output. Improve health or prevent chronic disease The Dietary Guidelines for Americans 2020-2025 (DGA) notes that the critical period for folic acid supplementation to prevent neural tube defects starts at least 1 month before conception and continues through the first 2 to 3 months of pregnancy [54]. The evolving role of multivitamin/multimineral supplement use among adults in the age of personalized nutrition. Multinutrients for the treatment of psychiatric symptoms in clinical samples: A systematic review and meta-analysis of randomized controlled trials. Common side effects may include: upset stomach; Am J Clin Nutr 2007:85:318S-22S. The immune system is strengthened by a number of active substances found in SP, including vitamins, minerals, carotenoids, polysaccharides, and linolenic acid [73]. Cobalamin. In another RCT of 18,314, smokers, former smokers, and asbestos-exposed persons, participants who took a combination of 30 mg/day of beta-carotene plus 25,000 IU/day of vitamin A (as retinol) had a 28% higher lung cancer risk than those taking a placebo after an average 4-year follow-up period [65]. After the investigators followed participants for up to 20 additional years, when participants were no longer taking the study supplement, the use of the MVMs during the RCT did not result in lower rates of total mortality or mortality from any cause of death examined, including cancer, heart disease, and stroke [45]. Vitamins and minerals serve crucial functions in almost all bodily processes and must be obtained from foods or supplements, as our bodies are unable to make them. [, Prentice RL. Minerals (especially taken in large doses) can cause side effects such as tooth staining . J Natl Cancer Inst 1993;85:1492-8. Vit. This page specifically discusses the use of multivitamins, which typically contain about 26 different vitamins and minerals, and often provide 100% of the Recommended Daily Allowance of these micronutrients. Nausea. Know the Science features a variety of materials, including interactive modules, quizzes, and videos, as well as links to informative content from Federal resources designed to help consumers make sense of health information. Participants in these studies used a wide variety of MVMs containing different combinations and amounts of nutrients. There are two different types of vitamin D, vitamin D3, which is the form . Ann Pharmacother 2011;45:476-84. Results from several studies demonstrate both the use of MVMs for nutritional insurance by some individuals and the potential of MVMs to lead to excessive intakes for others. Previous. One well-known trial of the impact of MVMs on both chronic disease risk and mortality used combinations of antioxidant nutrients. Some experts have hypothesized that MVM use might reduce the incidence of CVD or rates of deaths from this disease, possibly because certain nutrients in these products might reduce blood pressure or affect vascular function. Most studies of the potential value of MVMs to enhance health and prevent disease have been observational and compared individuals who chose to take MVM supplements with others who did not take supplements. Upper Limit. According to the federal governments 2020-2025 Dietary Guidelines for Americans, "Because foods provide an array of nutrients and other components that have benefits for health, nutritional needs should be met primarily through foods. [, Paranjpe MD, Chin AC, Paranjpe I, Reid NJ, Duy PQ, Wang JK, et al. [, Johnstone JM, Hughes A, Goldenberg JZ, Romijn AR, Rucklidge JJ. J Nutr 2016;146:1235-40. Dietary vitamins and minerals play ubiquitous roles throughout the human body by serving as veritable "helping hands" (e.g. MVMs for "senior" men and women, for example, often contain little or no iron and more calcium, vitamin D, and vitamin B12 than MVMs for younger adults [69]. However, MVMs cannot take the place of the variety of foods that are important to a healthy diet, because foods provide other nutrients and components that have benefits for health. This study prospectively followed 18,530 male physicians aged 40 years and older, of whom 20% reported taking an MV or MVM for an average of 12.2 years [24]. Nevertheless, some users consider use of an MVM as a form of dietary or nutritional insurance, a concept first introduced by Miles Laboratories to market its One-A-Day line of nutrient supplements in the 1940s [13]. [. Common side effects may include: upset stomach . Taking excess vitamin A (as retinol or other preformed forms of vitamin A but not beta-carotene) during pregnancy can increase the risk of birth defects in infants. : CD004905. Myoglobin helps your muscle cells store oxygen. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. Pediatrics 2008;122:1142-52. Deficiency Signs and Symptoms. Nutrition intervention trials in Linxian, China: Multiple vitamin/mineral supplementation, cancer incidence, and disease-specific mortality among adults with esophageal dysplasia. It is reasonably priced, and there's enough product to last a single cat about a month. These products go by various names, including "multis" and "multiples," and manufacturers determine the combinations and levels of vitamins, minerals, and other ingredients in them. JAMA 2017;317:183-9. [, Wang J-B, Abnet CC, Fan J-H, Qiao Y-L, Taylor PR. M. charantia maintains hypoglycemic effects through antioxidant effects promoting -cell protection and the decrease in glucose absorption from the intestines and glucose production from the liver by increasing hepatic glycogen and decreasing . Many of these products contain numerous ingredients in varied combinations and amounts. One way to group them is as follows (Table 1): An additional complication for this product category is that many dietary supplements are not labeled as MVMs even though they contain a variety of vitamins and minerals [1]. [, US Preventive Services Task Force. Vitamin B5. By age 71 or older, 48% of women and 43% of men were taking supplements. Risk of deficiency in multiple concurrent micronutrients in children and adults in the United States. Pharmacodynamics. The FNB does not address whether or to what extent nutrient supplements can compensate for dietary inadequacies. Based on this review, the USPSTF concluded there was insufficient evidence to determine "the balance of benefits and harms" in taking MVMs to prevent CVD or cancer [50]. Infants and children Some studies have suggested potential health benefits or harms from the use of MVMs, but others have found none. US Pharm. 2007;1:42-55. MVM supplementation, with or without the cocoa extract, improved global cognition, a benefit most pronounced in participants with a history of CVD. National Institutes of Health. Mechanism of action of Multivitamin Related doctor hospitals Pharmacy health centres, online consultation, second opinion for Multivitamin Mechanism of action of Multivitamin Published at: 14/11/2016 The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. Some electrolytes and water non-soluble vitamins require an active uptake mechanism. Office of Dietary Supplements. [, Park S-Y, Murphy SP, Wilkens LR, Henderson BE, Kolonel LN. Neither baseline use nor changes in use of MVMs over time were associated with changes in the long-term risk of major CVD events, MI, stroke, cardiac revascularizations, or death from CVD. Therefore, these terms refer to products that have widely varying compositions [5]. Normally provided in combination with dietary minerals. . The supplement did not reduce incidence or mortality rates for esophageal cancer or the rate of mortality from any cause. Among women, taking a daily MV or MVM did not affect their overall risk of developing cancer except for oropharyngeal cancer, which increased by 46%. Water and some water-soluble vitamins are absorbed by diffusion. Taking excess amounts of vitamin A (preformed retinol form, not as beta-carotene) during pregnancy has been shown to increase the risk of birth defects. Foods provide more than vitamins and minerals. It is found in various plants, including grapes, berries, peanuts, and red wine. Target Actions . During the study, 4,517 died of colon cancer. [, Lamas GA, Boineau R, Goertz C, Mark DB, Rosenberg Y, Stylianou M, et al. This raises questions regarding the safety of . Supplement Business Report 2021. Join the ODS Email List. Pregnant people Am J Clin Nutr 2015;101:144-52. Here are some of the key benefits of consuming red cabbage: Rich in nutrients: Red cabbage is a good source of vitamins and minerals, including vitamin C, vitamin K, vitamin A, potassium, calcium, and iron. The supplement also had no effect on cognitive decline with age [40]. Absorption of vitamins in the intestine is critical in avoiding deficiency states, and impairment of . People in the United States have taken multi-vitamin/mineral (MVM) and multivitamin (MV) dietary supplements since the early 1940s, when the first such products became available [1]. The Age-Related Eye Disease Study (AREDS), which was led by NIHs National Eye Institute and concluded in 2001, showed that daily high doses of vitamins C and E, beta-carotene, and the minerals zinc and coppercalled the AREDS formulationcan help slow the progression to advanced age-related macular degeneration (AMD), a blinding eye disease. Other RCTs have evaluated the effects of MVMs on outcomes in individuals with a range of chronic diseases. There is no one single thing that makes it work. Vitamin A (preformed = retinol; beta-carotene can be converted to Vitamin A) 700 micrograms (2,333 IU) 900 micrograms (3,000 IU) An evidence review commissioned by the U.S. Preventive Services Task Force (USPSTF) included 78 RCTs with 324,837 participants and 6 cohort studies with 390,689 participants [49]. Many foods also have fiber and other substances that can provide health benefits. The vitamin A UL during pregnancy is 2,800 mcg/day for adolescents and 3,000 mcg/day for women [66]. The model comprises an oxygenation that is coupled to carbon-carbon bond . This publication is not copyrighted and is in the public domain. Individuals who have poor nutrient intakes from diet alone, consume low-calorie diets, or avoid certain foods (such as strict vegetarians and vegans) might benefit from taking an MVM [60]. In 2006, researchers reviewed 63 published RCTs between 1966 and early 2006 that evaluated the potential impacts of MVs and MVMs and individual nutrient supplements on health and on the risk of certain medical conditions (cancer; age-related sensory loss; and cardiovascular, endocrine, neurologic, musculoskeletal, gastroenterologic, renal, and pulmonary diseases) [7]. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. MVMs providing nutrients in recommended amounts do not ordinarily interact with medications, with one important exception. A total of 41.5% of the women took an MVM (containing 2030 vitamins and minerals in amounts not exceeding the RDAs), an MV (10 or more vitamins in amounts of 100% or more of the RDA), or a "stress multisupplement" (containing at least 10 nutrients, some in amounts more than twice the RDA) at least once a week. [, Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, et al. MVMs and Use of Supplements Containing Individual Nutrients Found in MVMs Supplemental vitamins and minerals for cardiovascular disease prevention and treatment. When your child needs vitamin D, iron, and zinc. 1. US Preventive Services Task Force recommendation statement. Most main PEW biomarkers, the high WBC, the low absolute and percentage of lymphocytes in poorly controlled patients may be directly and/ or indirectly affected by their high Phe levels and/or low TAS levels in children with PKU on "loose diet". [, Sesso HD, Christen WG, Bubes V, Smith JP, MacFadyen J, Schvartz M, et al. Otten JJ, Hellwig JP, Meyers LD (editors). MVMs can also increase the likelihood that users will have intakes of some nutrients that are higher than the ULs [14]. A randomized trial. Brand Name: Generic Name: 32 Multivitamins & Multiminerals Dosage form: Tablet Indications: For the prevention and treatment of vitamins & mineral deficiencies as a complete daily nutritional supplement. Increase nutrient intakes [, Macpherson H, Pipingas A, Pase MP. Honey possesses antimicrobial, anti . For example, a manufacturer might label a product containing vitamins C and E, selenium, zinc, and beta-carotene as an antioxidant formula rather than an MVM. Vitamins and minerals can cause toxicity if consumed in large amounts. Because breastmilk provides little vitamin D, the American Academy of Pediatrics recommends that exclusively and partially breastfed infants receive supplements of 400 IU (10 mcg)/day of vitamin D beginning in the first few days after birth and continued until the infant is weaned and drinks at least 1 liter or 1 quart of vitamin D-fortified formula or whole milk daily [58]. Check with your physician for additional information about side effects. Approximately 48% of the men and 52% of the women in this study reported taking an MV or MVM. The compound is produced by plants as a defense mechanism against stress, injury, and infection. Therefore, the folic acid intakes of pregnant people who take these supplements and consume any foods fortified with this nutrient exceed the UL for this nutrient (1,000 mcg), even though many do not consume recommended amounts of folate from dietary sources alone [18]. Multivitamin use and colon cancer mortality in the Cancer Prevention Study II cohort (United States). October 11, 2022 BMJ Open 2020;10:e039119. Abstract Replacement of natural protein intake, low total antioxidant status (TAS) and DNA oxidation and high phenylalanine (Phe) blood levels are . Taking a basic MVM that provides nutrients in amounts that are approximately the same as recommended intakes should be safe for healthy people. The DGA also states that pregnant people might need to take separate supplements of iodine and choline when their health care provider recommends that they do so because many prenatal MVMs do not contain these nutrients or contain only small amounts of them. Inflammation is a biological response of the immune system that can be triggered by many factors, like microbes, infections, and damaged cells. Website: Vitamins A, C, D and E were used alone, in combination or with other nutritional and non . Multivitamins with iron are used to provide vitamins and iron that are not taken in through the diet. Long-term multivitamin supplementation and cognitive function in men: A randomized trial. The mineral fluoride not only helps bone formation but also keeps dental cavities from starting or worsening. Dark stools. Vitamin and mineral supplements for the primary prevention of cardiovascular disease and cancer. Whether studies find any benefits (or risks) of MVMs depends in large part on the combinations and amounts of nutrients in the MVMs used, and these studies' results are not generalizable to the enormous variety of MVMs available in the marketplace. Vomiting. [, Mulholland CA, Benford DJ. Minerals (especially taken in large doses) can cause side effects such as tooth staining, increased urination, stomach bleeding, uneven heart rate, confusion, and muscle weakness or limp feeling. RCTs have focused primarily on the link between MVM use and CVD (or all-cause mortality) outcomes. But taking an MVM can also raise the chances of getting too much of some nutrients, like iron, vitamin A, zinc, niacin, and folate/folic acid, especially when a person takes more than a basic, once-daily product that provides 100 percent of the daily value (DV) ofnutrients. [, Jacobs EA, Connell CJ, Patel AV, Chao A, Rodriguez C, Seymour J, et al. In the Age-Related Eye Disease Study (AREDS), investigators randomized 4,757 individuals aged 5580 years who had varying degrees of AMD, cataract, or both conditions to receive a placebo or a daily supplement containing high doses of vitamin C (500 mg), vitamin E (400 IU), beta-carotene (15 mg), zinc (80 mg), and copper (2 mg) [30,31]. MVMssuch as those for energy, enhanced athletic performance, weight control, improved immune function, or eye healthoften combine several vitamins and minerals with botanical and specialty ingredients, such as coenzyme Q10, probiotics, or glucosamine. Vitamins & Minerals; Supplier Directory; . Use rates by sex and age are 19.5% for men and 26.1% for women ages 1930 years, 25.1% for men and 33.0% for women ages 3150 years, 34.5% for men and 36.2% for women ages 5170 years, and 40.9% for men and 44.0% for women ages 71 years and older. The main mechanism of action is through its ability to boost metabolism, reduce appetite, and increase energy levels. The DGA adds that infants fed human milk might also require a vitamin B12 supplement if the mother's vitamin B12 status is inadequate, which might occur, for example, if she follows a vegan diet [54]. Examples of these populations are described below: People who could become pregnant Among children and adolescents, MVM use rates were 11.0% for up to 2 years of age, 34.6% for ages 25 years, 29.5% for ages 611 years, and 17.3% for ages 1219 years [11]. Vitamins are organic molecules necessary for normal metabolism in animals, but either are not synthesized in the body or are synthesized in inadequate quantities and must be obtained from the diet. Am J Clin Nutr 2007;85:308S-13S. [, Christen WG, Glynn RJ, Manson JE, MacFadyen J, Bubes V, Schwartz M, et al. Challenges and opportunities in the translation of the science of vitamins. * This fact sheet focuses primarily on these basic, broad-spectrum MVMs. This is the essential step leading to carboxylation and activation of the blood-clotting proteins. Multivitamins/multiminerals (MVMs) are the most frequently used dietary supplements, with close to half of American adults taking them. JAMA Network open 2019;2(6):e195967. Multivitamin/mineral supplements (MVM) are widely used in many populations. MVM supplementation modestly but significantly reduced users' risk of developing cancer by 8% but did not reduce the risk of any type of cancer (e.g., of the prostate or colon) or overall cancer mortality [39]. For example, 27.7% had inadequate intakes of vitamin A from foods alone, but this rate dropped to 15.5% when supplements were included. Each of the product's ingredients works to enhance your health and well-being. Am J Clin Nutr 2022;115:1501-10. However, individuals who take MVMs and other supplements and who consume fortified foods and beverages might obtain some nutrients in amounts exceeding the UL, increasing the possibility of adverse effects [62]. Multivitamin use and the risk of cardiovascular disease in men. Molecules, 24 (2019), p. 2362, 10.3390/molecules24132362. ET, or . Nutritional vitamins B-1, B-2, B-6 and PP can enhance matter-energy metabolism and protein metabolism and to forestall the formation and the buildup of the parts related to power metabolic syndromes and ageing in organisms and strengthen the physique's well being by way of their synergistic results (Wang, et al. The studies included a total of 91,074 healthy adults (average age 62 years) taking the MVs or MVMs for an average of 43 months, and the investigators reported 8,794 deaths. Health care providers sometimes prescribe MVMs for people who have medical conditions and diseases that impair digestion, absorption, or use of nutrients. Some evidence from RCTs has focused on the use of MVMs to reduce the risk of various chronic diseases. The FNB and DGA agree that fully and partially breastfed infants should receive a supplement containing approximately 400 IU (10 mcg)/day vitamin D beginning in the first week of life [54,59]. How to use Theragran-M oral. Secondary metabolites. Institute of Medicine], Food and Nutrition Board. Cancer Causes and Control 2001;12:927-34. Cancer An earlier analysis of 20112014 NHANES data found that 31.2% of the U.S. adult population aged 19 years and older reported taking an MVM in the past 30 days [2]. Nutri-Vet has provided us with their Multi-Vite Paw-Gel for cats that is the best overall supplement available. Studies of MVMs that have focused on cancer have been observational. MVMs taken once a day that contain all or most vitamins and minerals, most in amounts that do not exceed the Daily Values (DVs), Recommended Dietary Allowances (RDAs), or Adequate Intakes (AIs) for these nutrients. Vitamin A is effective for the treatment of Vitamin A deficiency. U.S. Department of Agriculture and U.S. Department of Health and Human Services. Introduction. Overall, MVMs do not appear to reliably reduce the risk of chronic diseases when people choose to take these products for up to a decade (or more) or when studies randomize people to take them as part of a clinical trial. Studies of the association between MVM use and CVD outcomes have focused on several outcomes, including cardiovascular events and mortality. [, Jenkins DJA, Spence JD, Giovannucci EL, Kim Y-I, Josse RG, Vieth R, et al. Prevalence of dietary supplement use in US children and adolescents, 2003-2014. The mechanism of action of vitamin K is discussed in terms of a new carbanion model that mimics the proton abstraction from the gamma position of protein-bound glutamate. RCTs Men. Ann Intern Med 2013;159:797-805. Nutrients 2018, 10, 248. Even in the United States, the amount of folic acid in prenatal MVM supplements is typically 800 or 1,000 mcg, which is much higher than the recommended amount (400 mcg) to reduce the risk of neural tube defects in babies [19]. The trials included 141,849 pregnant people from low- or middle-income countries in Africa and Asia as well as in Mexico (where malnutrition and micronutrient deficiencies are not uncommon); only one of the studies was conducted in a high-income country, the United Kingdom. J Am Coll Cardiol 2021;77:423-36. Multivitamin and multimineral dietary supplements: definitions, characterization, bioavailability, and drug interactions. In one study, for example, investigators assessed the diets and use of MVMs in a large multiethnic cohort of 90,771 men and women ages 45 and older from Los Angeles and Hawaii [16]. Read the label of any multivitamin product you take to make sure you are aware of what it contains. JAMA 2012;308:1871-80. Some MVMs contain amounts of some vitamins and minerals that are substantially higher than the DV, RDA, AI, or even, in some cases, the established Tolerable Upper Intake Level (UL). The mechanism of action of resveratrol is complex and not fully understood. Inflammation comes from the Latin word inflammare, which means "to set on fire.". Minerals (especially taken in large doses) can cause side effects such as tooth staining, increased urination, stomach bleeding, uneven heart rate, confusion, and muscle weakness or limp feeling. [. MVMs and MVs accounted for 14% of all purchases of supplements and 38% of all sales of vitamin and mineral supplements in the United States in 2019 [4]. Alzheimer's & Dementia 2022;1-12. The products provided an average of 14 nutrients, although the products with 3 nutrients in 5 trials did not contain a mineral. We will explore situations that a multivitamin may be health-promoting, as well as if there is a benefit or harm in taking extra nutrients . Multiple outcomes Men who took a daily MV or MVM had a 2% higher overall risk of cancer, including a 3% higher risk of prostate cancer, 8% higher risk of lung cancer, and a 16% higher risk of leukemia (which increased to 26% higher if they took more than one MV or MVM daily). Eye floaters are small, semi-transparent specks or cobweb-like substances that appear to float in the eye's vitreous humor, which is the clear, gel-like fluid that fills . Sometimes a member of your CF care team will ask you to take a single nutrient vitamin supplement, such as vitamin D. Most single nutrient vitamin supplements are available over the counter, although some require a prescription.. [, Bailey RL, Fakhouri TH, Park Y, Dwyer JT, Thomas PR, Gahche JJ, et al. A 5000Units (40% as beta carotene), thiamine 1.5mg, riboflavin 1.7mg, niacinamide 20mg, pantothenic acid 10mg, pyridoxine 2mg, Vit. One team of researchers categorized MVMs more ambiguously as "stress-tab-type," "therapeutic type," and "one-a-day type," so these products probably included MVs as well [8]. In some cases, fortified foods and dietary supplements are useful when it is not possible otherwise to meet needs for one or more nutrients (e.g., during specific life stages such as pregnancy" [54]. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. Revitalize Multi-vitamin and Mineral Complex: Iron (1.5 mg / cap) + Ascorbic acid . Acknowledging that most health care providers recommend that pregnant people take a daily prenatal MVM, the DGA states that this practice may be necessary to meet the needs for folate or folic acid, iron, iodine, and vitamin D during pregnancy [54]. [, Gaziano JM, Sesso HD, Christen WG, Bubes V, Smith JP, MacFadyen J, et al. Furthermore, investigators define MVMs differently (or sometimes not at all) in their studies to evaluate the potential health effects of these products. Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial. However, evidence to support their use for overall health or disease prevention in the general population remains limited. MVM supplementation did not have a beneficial or harmful effect on risk of stillbirths or of perinatal and neonatal mortality in comparison with iron and folic acid supplementation. The trial in the United Kingdom that compared an MVM to a placebo found no beneficial or harmful effect of the MVM on preterm births, birth at a smaller size than normal gestational age, or low birth weight. Well, different vitamins and minerals in a prenatal vitamin work in different ways. Clinical trials, where individuals are randomly assigned to take the dietary supplement or a placebo, are better than observational studies for determining whether MVMs might affect disease risk. 8. Multivitamins, vision are an over-the-counter (OTC) product used to reduce the risk of vision loss among moderate to advanced age-related macular degeneration (AMD) patients and as an ocular (eye) vitamin supplement. Obimin Plus is a pre- and postnatal supplement to help provide adequate supply of vitamins, minerals and DHA and EPA, during pregnancy and lactation. Clinical trials and observational studies to assess the chronic disease benefits and risks of multivitamin-multimineral supplements. One RCT randomized 1,708 participants aged 50 years and older who had had an MI at least 6 weeks earlier to take a daily MVM containing 27 nutrients (many in doses higher than recommended amounts) for a median of 31 months (range 13 to 60 months) or a placebo as well as their standard medications. Take your multivitamin with a full glass of water. Blumberg JB, Bailey RL, Sesso HD, Ulrich CM. U.S. Preventive Services Task Force. Although MVM use might not reduce overall chronic disease risk, several nutrients in MVMs might benefit certain groups of people. . Overall, women are more likely (34.0%) to take an MVM than men (28.3%) [2]. Because people with healthier diets and lifestyles are more likely to use dietary supplements, attributing health benefits that are distinct from the benefits of healthy behaviors to the use of supplements is difficult [13]. [, Rautiainen S, Lee I-M, Rist PM, Gaziano JM, Manson JE, Buring JE, Sesso HD. They have examined associations between MVM use and overall cancer risk or risk of various types of cancer (including breast, prostate, and colon cancer) as well as associations with cancer-related death. The result is often a fresh perspective on . [, Qato DM, Alexander GC, Guadamuz JS, Lindau ST. Excess intakes can also be a concern for people taking MVMs that contain some vitamins or minerals in amounts approaching or exceeding the UL.