Good morning, PMC Ive made a 80% recovery so far and I keep improving however your hypothesis is quite scary. The Impact of 5-Reductase Inhibitor Use for Male Pattern Hair Loss on Men's Health. According to the Post-Finasteride Syndrome Foundation, these may include: Reduced memory and difficulty recalling information, Impaired ability to solve problems and comprehend information, General cognitive impairment and slowed thought processes, Depression, anxiety and/or suicidal ideation, Anhedonia (inability to feel pleasure) and emotional flatness, Insomnia (difficulty falling asleep or staying asleep). I have had PFS for 15 years, just came across your article, would you be interested in looking at my labs for comment? Although vitamins dont play a role in preventing male pattern baldness, many vitamins are vital for proper hair growth. Research has shown that finasteride cuts DHT levels in the prostate by upwards of 90 percent, and by more than 70 percent in the bloodstream. Learn more about our editorial standards here. 8600 Rockville Pike Customers were given free product.. https://www.ncbi.nlm.nih.gov/books/NBK513329/, https://www.niddk.nih.gov/health-information/urologic-diseases/prostate-problems/prostate-enlargement-benign-prostatic-hyperplasia, https://www.pfsfoundation.org/about-pfs-post-finasteride-syndrome/, https://www.pfsfoundation.org/frequently-asked-questions/, https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/020788s028lbl.pdf, https://www.karger.com/Article/Fulltext/497362, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401955/, https://pubmed.ncbi.nlm.nih.gov/17655657/, https://pubmed.ncbi.nlm.nih.gov/27662439/, https://medlineplus.gov/genetics/condition/androgenetic-alopecia/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540144/, https://www.ncbi.nlm.nih.gov/books/NBK482378/, https://www.scitcentral.com/article/19/60/Randomized-Comparative-Research-Study-of-Topical-and-Oral-Finasteride-with-Minoxidil-for-Male-Pattern-Androgenetic-Alopecia-in-Indian-Patients, https://www.ijord.com/index.php/ijord/article/view/394, https://rarediseases.info.nih.gov/diseases/12407/adverse-events-of-5-alpha-reductase-inhibitors, many vitamins are vital for proper hair growth. An official website of the United States government. Glycine about 5g daily and niacinamide about 500mg-1g daily. Post-finasteride syndrome is a term thats used to refer to a range of symptoms associated with the use of finasteride as a treatment for hair loss and benign prostatic hyperplasia. Im with my mum at the moment shes on a couple of acres so decent amount of space to move about! We strive to use primary sources and refrain from using tertiary references. I would appreciate some specific help if you could get back to me. From frail and hypogonadal, to gaining 60lbs of muscle, boosting testosterone over 1,000ng/dl and becoming a successful entrepreneur. Weve explained what post-finasteride syndrome is, the symptoms that are associated with PFS, as well as the potential treatment options for men who have issues after using finasteride. government site. You do think that these hypothetical damages can be reversed ? Epub 2018 Oct 6. Any other advice that would help is greatly appreciated. Unlike regular finasteride side effects, post-finasteride syndrome is designed as persistent side effects from finasteride that can continue after the medication is discontinued. FOIA Berrima in the Southern Highlands in NSW, its a beautiful area. WebPost-Finasteride Syndrome (PFS) is a term used to describe a complex of symptoms with persistent sexual, neurological, mental, and physical side effects in patients who usually have taken treatment for hair loss, such as Finasteride (marketed under the brand name Propecia or generics) or for enlarged prostate (marketed under the brand name On the other hand, there are reports of people developing PFS within a few days of stopping finasteride. Have you tried getting loads of sunlight? The bottom line is that no one knows if tapering off is safer than abruptly discontinuing the drug. Considering the amount of stress in our daily lives and the constant negative feedbacks from exogenous estrogens leading to GNRH suppression, HCG is probably the best drug there is on the market right now. The depression of PFS can be very debilitating and finding effective treatments for the depression of PFS can be challenging and require considerable trial and error in consultation with your doctor. After nearly 4 years of suffering, I have finally & fully recovered from Post Finasteride Syndrome. I just picked up Gaba, im assuming this is a good idea? HIMS, HERS, H, and HIMS & HERS are trademarks of Hims, Inc. Get medication to your doorstep, if prescribed. Discussion in 'My Optimal Journal' started by JPB, Dec 31, 2018. Hey Peterson, Like other medications, finasteride went through several large-scale clinical trials before it finally received approval from the FDA. Clinically proven to regrow hair in 3-6 months, no pills required. Currently, finasteride is the most effective option available for treating hair loss. A few good ways to lower serotonin include: For a more comprehensive guide on lowering serotonin, check out this article: Apart from just focusing on hormones and neurotransmitters, you can also focus on diet and lifestyle. Feel free to discuss remedies, research, technologies, hair transplants, living with hair loss, cosmetic concealments, whether to "take the plunge" and shave your head, and how your treatment progress or shaved head or hairstyle looks. You also may want to look into using topical finasteride to treat your hair loss. synthesis of bile (5-R specifically), which is essential for the digestion of fat and absorption of fat-soluble vitamins. 2019 Jan 1;99(1):12-17. doi: 10.2340/00015555-3035. Press J to jump to the feed. No libido So far I tread Clomid and nolvadex cycles but I only had one day where libido returned, rest of time didnt feel anything good or bad when on it. Im not beholden to trT. (For a complete list of reported PFS symptoms, see our About Post-Finasteride Syndrome page. I have blood and hormones test results if u want. For symptoms other than PED, no similar statistical analyses involving critical masses of patient records have yet been published. is a recovery really possible? Like clomid, nolvadex, HCG? Muscle pain Q8: I cant find a doctor in my area whos familiar with PFS. Its available as a liquid and as a foam and is applied directly to the areas of your scalp affected by male pattern baldness. Post-finasteride syndrome is characterized PMC Outcomes after discontinuation of finasteride Dysfunctions By blocking the conversion of testosterone to DHT, finasteride drastically reduces DHT levels in the body. Love the site. In mouse models PEA increased brain allopregnanolone levels and reduced anxiety-like and depression-like behaviors. It appears promising that treatment with PEA, by increasing allopregnanolone levels in PFS patients brains, could improve mood and reduce anxiety. Sure I can do that for you. For example, according to the Post-Finasteride Syndrome Foundations FAQs page, there is no known cure for post-finasteride syndrome, nor are there any known scientific reports of patients with post-finasteride syndrome returning to full health. One way to treat your hair loss without using finasteride is to use non-prescription treatments for hair loss, such as minoxidil, hair loss shampoo and hair growth vitamins. When it comes to the side effects of medication, especially severe ones, its important to look at data objectively. I have had retraction of penis and man boobs. It was described that the prolonged use of 5-steroid reductase inhibitors in patients with alopecia can cause persistent side effects called a post-finasteride syndrome (PFS), that is not just a simple coexistence of events, but rather a definite syndrome with an iatrogenic background. 2015 Sep;16(3):177-98. doi: 10.1007/s11154-015-9319-y. My hypothesis is that finasteride can cause brain damage which needs to be reversed. Sex Med Rev. Low levels of these hormones increase glutamate and may account for the appearance of behavioural disorders such as anxiety, aggression, and cognitive dysfunction. This site needs JavaScript to work properly. Finasteride, which is sold as a generic and under the brand name Propecia, is one of the most popular medications on the market for treating and preventing male pattern baldness. So thankful to have found this article. Unauthorized use of these marks is strictly prohibited. This reduction in DHT greatly reduces prostate growth and either slows down, stops or reverses hair loss caused by male pattern baldness. >1000ng/dl Testosterone: My Step-by-Step Guide on How I Do It Naturally! 2019 Apr;7(2):277-282. doi: 10.1016/j.sxmr.2018.07.003. Yes, in general its safer with less sides, but some people have reported similar side effects as fin. After registration is submitted, you will receive a confirmation email, which should contain a link to confirm your intent to register for the forum. Biomolecules. In general, side effects from finasteride are rare, with only a small percentage of men affected at the typical finasteride dosage used to treat hair loss. I just want to make sure i dont make any mistakes. Im in PFS from February 2018. Online ahead of print. Its pretty astounding the improvement in symptoms since the move. Vitamin C for erectile dysfunction: the best vitamin for ED? Some might be upregulated and some downregulated, so you might experience heightened serotonin responses. I haven't tried Fens, but relate to the brainfog and depression and no morning wood or it getting spontaneously glorious. Some research suggests that more than 50 percent of men in will experience some form of hair loss by the time they hit 50 years old. Over time, it has been considered a safe and well If youve searched online for information about these side effects, you may have come across mentions of long-lasting, persistent issues that are referred to as post-finasteride syndrome, or PFS. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Accessibility However, the PFS Foundation strongly discourages the use of finasteride for hair loss by anyone. Before Traish AM, Melcangi RC, Bortolato M, Garcia-Segura LM, Zitzmann M. Rev Endocr Metab Disord. Dopamine agonists, such as mucuna pruriens, huperzine A, Catuaba bark extract, etc. Yep, the medical system doesnt care about what happens to you. Rzeszotek S, Kolasa A, Pilutin A, Misiakiewicz-Has K, Sielatycka K, Wiszniewska B. Biomedicines. National Library of Medicine However, it can shift hair follicles into the anagen, or growth, phase of the hair growth cycle, which stimulates growth. WebFinasteride is a 5-reductase enzyme inhibitor that has been approved for the treatment of male androgenic alopecia since 1997. i been suffering for close to a year from just 3 weeks of usage. I want to try HCG 50 UI per day. Both are inconsistent. Alongside thyroid. This site uses Akismet to reduce spam. And then you would possibly absorb better the UV. Alternatively, you can use other treatments, such as those available in our Non-Prescription Hair Loss Kit, to treat male pattern baldness without taking oral finasteride. official website and that any information you provide is encrypted Sure man. (Her story begins around 16:10.). Unauthorized use of these marks is strictly prohibited. A: Yes. I found some recovery stories with these compounds. Book Full Body Checkups. This is a great video Ive shared many times over many HRT forums. Also I jumped the gun on TRT out of frustration and desperation. Published by Elsevier Inc. All rights reserved. However, there have been no published medical studies that report on the effectiveness of SSRIs to treat PFS. Premature ejaculation: the ultimate guide to fix it for good, Honey for erectile dysfunction: the sexual aphrodisiac food. ARE THE SEXUAL SIDE EFFECTS WORTH THICK HAIR? If cortisol is low in blood tests, then you can focus on increasing that, but if cortisol is low in saliva tests but high in blood tests, focus on calming the adrenals. Do you have any digestive issues? Huh? In the meantime, we are working hard to publish as much medical literature and other news about the condition as possible on our website. What is Post Finasteride Syndrome (PFS)? Q17: Can finasteride have an impact on male fertility? WebPost-finasteride syndrome (PFS) describes persistent sexual, neurological, physical, and mental adverse reactions in patients who have taken finasteride, a 5-alpha reductase type - PubMed - NCBI, Penile Growth in Response to Human Chorionic Gonadotropin (hCG) Treatment in Patients with Idiopathic Hypogonadotrophic Hypogonadism, Low-Dose Human Chorionic Gonadotropin Maintains Intratesticular Testosterone in Normal Men with Testosterone-Induced Gonadotropin Suppression, Elevated ESR and hCG levels are strong predictors of impending cancer diagnosis To Extract Knowledge from Matter, Thoughts On 5ar And Post Finasteride Syndrome, Post Finasteride Syndrome And Low Insuline, Post Finasteride Sydrome - Neuropathic Pain, Low-Dose HCG Maintains Intratesticular T In Normal Men With T-Induced Gonadotropin Suppression, DHT And Reversing Androgen-receptor Deficiency, Elevated ESR And HCG Levels Are Strong Predictors Of Impending Cancer Diagnosis, Post Finasteride Sydnrome, And The 5ar1 And 2 Isoenzymes, Post Finasteride/ High Cortisol/ Low Gaba. In 2013, Swiss pharmaceutical company Polichem SA conducted a study, published in the Journal of the American Academy of Dermatology and titled Single and repeated dose of finasteride topical solution in subjects with androgenetic alopecia, which showed that topical finasteride is absorbed and lowers serum DHT levels almost to the same degree as the oral medication. Glycine, Agmatine, and Pregnenolone can also help increase ALLO. If I work out too much or my job is extra stressful I become symptomatic. Before Listed there are more than 80 doctors, psychologists and pharmacologists who counsel PFS patients and their family members. For a better experience, please enable JavaScript in your browser before proceeding. (It is not known if PED in that subset ever subsided, or persisted.) Epub 2018 Oct 6. No one knows for sure. I also started taking Allopregnalone ( Ideal Labs ) along with coconut oil whcih has helped with my mood and anxiety. Its sold under the brand names Propecia and Proscar. When used together, men saw better results in clinical trials compared to using either alone. Disclaimer. I got Post Accutane Syndrom, which is related to PFS, there is a down regulation of 5 alpha reductase 1. I think he would suggest you "train" your skin to absorb more UV buy doing that yeah. This is a difficult question to answer as there is a small minority of PFS patients who have reported anecdotally that they have developed PFS only after quitting finasteride. Other PFS patients anecdotally report PFS symptoms while using finasteride that get worse after quitting the drug. This was a single center, prospective case-control study taking place between March 2013 and September 2018. Q6: How long before an effective treatment for PFS is developed? In some cases, there was no difference in side effect rates between the two treatments. Palmitoylethanolamide (PEA) is a substance naturally produced in many cell types in our bodies, including in very high concentrations in our brains. Doses have ranged between 1200mg and 3600mg per day without significant side effects. This is a difficult question to answer as there is a small minority of PFS patients who have reported anecdotally that they have developed PFS only after quitting finasteride. Like finasteride, dutasteride (brand name Adovart) is a 5-alpha-reductase inhibitor that has a similar chemical composition. If youre concerned about post-finasteride syndrome, sexual symptoms or other side effects, its important to discuss them with your healthcare provider before using finasteride. Finasteride is known to deplete Allopregnanolone and this supplement should help you increase it which may provide relief to brain fog, depression, or insomnia. A functional medicine doctor would help, but anything outside of health insurance coverage is out of my reach for the moment. I know, that there are people who recoveredTo you PLEAAASE post some encouraging stuff for the rest of us.. Im 5 weeks off propecia, und total numbness in my penis, low libido, suicide ideation und shooting pain in my shaft.. I think androsterone and allopregnanolone, or topical DHEA and progesterone would be good options. I also had dysbiosis in my gut which is slowly being resolved with the help of probitics. Several different methods are used in hair transplant surgery, including follicular unit extraction (FUE) and follicular unit transplantation (FUT). progesterone -dihydroprogesterone (a very important neuroactive steroid and precursor to allopregnanolone), deoxycorticosterone dihydrodeoxycorticosterone (DHDOC), cortisol 5-dihydrocortisol (for the deactivation of cortisol), aldosterone 5-dihydroaldosterone, which increases the excretion of salt, the opposite of aldosterone, dry skin or thinning of the skin, weight gain, elevated glucose and lipids and worsening of insulin sensitivity(, diminished libido, erectile dysfunction, ejaculatory complaints, penile discomfort, loss of scrotal sensitivity, scrotal discomfort, loss of pubic hair, increased sperm density and, Alcohol (not a long term or good strategy really). Clipboard, Search History, and several other advanced features are temporarily unavailable. MeSH This article is for informational purposes only and does not constitute medical advice. Unfortunately, medical science has yet to determine which factors, genetic or otherwise, make patients disposed to developing the condition. 2021 Jun;44(6):1263-1273. doi: 10.1007/s40618-020-01424-0. 8600 Rockville Pike Bone pain Please note that the PFS Foundation is not a medical organization and, as such, does not offer medical advice. In other words, the biological According to the Post-Finasteride Syndrome Foundation, these may include: Natural solution without any success. Q10: When I sought treatment for PFS from my doctor, all he did was prescribe antidepressants. The men in one group were informed that they would use finasteride and told about the sexual side effects associated with the medication. PEA has been studied in 40 clinical trials involving 6000 subjects over the years and has shown a quite favorable risk/benefit ratio. It is a severely underrated and misunderstood drug. All these factors would indicate that tapering off finasteride offers no advantage compared to abruptly stopping the drug. However, it does raise questions about the theory that finasteride has the potential to cause lasting, long-term, severe side effects. I will start Progesterone cream with tongkat ali soon. Are antidepressants safe for PFS patients? Some people actually report dramatic improvements in their symptoms after starting a certain SSRI. MeSH Minoxidil is a topical medication for treating hair loss. Ive read about him saying this is pro-fat metabolism and Haidut has an article on how hCG is considered a marker for cancer when it is in fact a promotor of cancer in itself because it trigger cell growth. It would be something if I could get referred to an endocrinologist and expect some understanding, but my impression is thats not how it goes. Oral testosterone: Hows the best way to take it? One key indisputable clinical evidence noted in all reported studies with finasteride and dutasteride was that use of these drugs is associated with development of sexual dysfunction, which may persist in a subset of men, irrespective of age, drug dose or duration of study. A deterioration in the quality of life in affected individuals does not justify use of the drug. WebPost-finasteride syndrome (PFS) is a constellation of serious adverse side effects manifested in clinical symptoms that develop and persist in patients during and/or after discontinuing finasteride treatment in men with pattern hair loss (androgenetic alopecia) When you send us your Patient Support form, include a note in your email letting us know youd specifically like to connect with fellow PFS patients who are willing to share their coping strategies. Practo Plus. An Bras Dermatol. JoeKool said: After nearly 4 years of suffering, I have finally & fully recovered from Post Finasteride Syndrome. A small subset of patients claims hormonal, psychological, and neurological symptoms that persisted despite stopping taking the medication. For diagnostic criteria of the condition, see our PFS Diagnostic Criteria page.). There are some nice recovery stories on TR. My goal is to get off Trazodone as quickly as possible, any recomendationsto further aid with insomnia ? Topical TRT will increase DHT even more. PFS occurs in susceptible individuals even after small doses of the drug and can last for a long time after the discontinuation of treatment. Use Catuaba bark extract, mucuna pruriens, Tribulus Terrestris, etc. HHS Vulnerability Disclosure, Help Good hypothesis! Finally, another way to treat male pattern baldness without using finasteride is via hair transplant surgery. At first glance, this may look concerning. For example, in a one-year trial, men with male pattern baldness who were treated with 1mg of finasteride per day reported the following side effects: Decreased libido (reported by 1.8 percent of men), Erectile dysfunction (reported by 1.3 percent of men), Ejaculation disorder (reported by 1.2 percent of men). But always do blood tests first to see what is really going on. From 50UI per day. 2022 Hims & Hers Health, Inc. All rights reserved. Q13: I understand we dont know which is riskier, quitting finasteride or staying on it, but I still want to quit. Q18: Can topical finasteride cause PFS in the same way that oral finasteride does in some men? The program can also connect the loved ones of PFS patients who have taken their own lives with the loved ones of other PFS patients who suffered the same fate. Huperzine-A, Uridine, Bacopa Monnieri, Phosphatidylserine, Alpha-GPC, Caffeine. HCG will most likely increase progesterone, but hopefully, it can stimulate 5AR which will increase allopregnanolone. Ruksiriwanich W, Linsaenkart P, Khantham C, Muangsanguan A, Sringarm K, Jantrawut P, Prom-U-Thai C, Jamjod S, Yamuangmorn S, Arjin C, Rachtanapun P, Jantanasakulwong K, Phimolsiripol Y, Barba FJ, Sommano SR, Chutoprapat R, Boonpisuttinant K. Plants (Basel). However, its still possible to take action and reduce the severity of your hair loss without using finasteride. T-Hero review: a meh or great testosterone booster? After finasteride is discontinued, the body must produce new 5-alpha-reductase molecules to replace the ones that were inactivated by the finasteride. These serious adverse side effects include persistent or irreversible sexual, neurological, physical and mental side effects. Finally, weve explained your options for treating and preventing hair loss if youre worried about developing post-finasteride syndrome. The men in the other group were not told that they would use finasteride and did not receive a briefing on potential side effects. See? This issue can have a serious impact on a persons risk of experiencing side effects after taking medication, as healthcare providers are required to inform their patients about the potential side effects of medication as part of the treatment process. Important: FOR MEDIA ONLY. If youd like to suggest adding one, please email patient manager Philip Roberts at proberts@pfsfoundation.org.). Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of Allopregnanolone in Adult Male Rats. Could this cause any bad results that you can think of? These constellations of symptoms constitute the basis for PFS in individuals predisposed to epigenetic susceptibility. It is known that post-finasteride syndrome (PFS) patients suffer from treatment-resistant depression and anxiety. there is a big thread about the Aussie donut hole - where JK gave us tons of info. An observational retrospective evaluation of 79 young men with long-term adverse effects after use of finasteride against androgenetic alopecia. As for hair loss shampoos, many include ingredients such as ketoconazole and saw palmetto to block DHT at the scalp level. Its also worth noting that in practice, most hair transplantation surgery patients are treated with finasteride before and after the procedure. Q3: Why do some finasteride patients develop PFS while others never seem to have any problems with the drug? The Post-Finasteride Syndrome Foundation was founded in 2012 to support research into post-finasteride syndrome, a term use by some researchers to describe persistent side effects of the drug. This condition, termed post-finasteride syndrome (PFS) is characterized by sexual side effects (i.e., low libido, erectile dysfunction, decreased arousal and difficulty in Bile also acts as an anti-bacterial and anti-microbial substance which keeps the gut clean and prevents SIBO and SIFO. How do you explain that? I think its a combination of low energy production due to cellular damage and excess ROS production. The first of these is the nocebo effect. I think progesterone is high because its not converted further downstream possibly due to 5AR downregulation. My blood level are ok only progesterone and colesterolo are higher than the max range. But the PFS Foundation is working as fast as possible to facilitate research that promises to identify the underlying biological mechanisms of PFS while laying the groundwork for the identification or development of effective therapies. Our Support staff will manually approve your account within 24 hours, and you will get a notification. My test blood is perfect. Kaplan-Marans E, Sandozi A, Martinez M, Lee J, Schulman A, Khurgin J. Who would have thought trying to enhance the hairline would cause bigger problems! Replacing testosterone helps recover the DHT receptors and is the only treatment known. Feel free to reach out to any of them with questions you might have, including appointment requests. They report very high stress symptoms, which often develops into an episode of panic attack or anxiety attack. At this point, you will not yet be registered on the forum. Q11: Id like to get in touch with other PFS patients in my area, or anywhere in the world, for that matter. Adverse effects of 5-reductase inhibitors: What do we know, don't know, and need to know. As a result of this, most medical bodies do not officially recognize post-finasteride syndrome as a medical condition. WebDr Jordan Grant and Gil T talk about Post Finasteride Syndrome Recovery (PFS recovery). Many men begin to develop sexual performance issues in middle age. I am doing a High sensativity blood panel soon, would you be able to also look at my blood work to see what could be the problem with everything i am experiencing?Thanks. 2022 May 5. doi: 10.1038/s41443-022-00568-2. It scrambles your hormones, libido and cognition all over the place, right into the gutters, and leaves you feeling like an empty dysfunctional husk. sharing sensitive information, make sure youre on a federal Practo Health Feed. Dutasteride was the second inhibitor to be approved and has a similar safety profile. Im a newbie here so dont hold me very accountable here. The .gov means its official. Perhaps you mean hgh ? Minoxidil doesnt block DHT. This site needs JavaScript to work properly. Do you sleep in a tent? After 15 years of research i also believe mycotoxins are playing a big role in this, mycotoxins damage the grey matter in your brain which would cause dopamine issues, then a cascade of issues from hpa axis dysfunction, gut issues, hormone issues which wont go away under a complete mycotoxin detox is done. Individual results will vary. (You must log in or sign up to reply here. Thank you so much for your time. Disproportionality analysis based on both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) pharmacovigilance databases. Hair transplant surgery provides permanent results, but it can be costly. Whats happening to the progesterone if I try HCG? But if youd like to sign up as a willing candidate ahead of time, please email proberts@pfsfoundation.org and well note it in our database. The study also showed that the longer men are on finasteride, the more likely they are to develop PED. Im wondering if that Has to do with gut health. It has a population of 666. We offer a combination Topical Finasteride & Minoxidil Spray that allows you to get the benefits of finasteride and minoxidil in a single medication. Post-finasteride syndrome (PFS) is a constellation of serious adverse side effects manifested in clinical symptoms that develop and persist in patients during and/or after discontinuing finasteride treatment in men with pattern hair loss (androgenetic alopecia) or benign prostatic hyperplasia. Its really not the serotonin thats so beneficial. Unfortunately, there have also been no published medical studies that report on the effectiveness of other antidepressants in the treatment of depression associated with PFS. A similar trend occurred in trials of Proscar, a 5mg form of finasteride thats used to treat benign prostatic hyperplasia. It is important to note that many clinical studies suffer from incomplete or inadequate assessment of adverse events and often limited or inaccurate data reporting regarding harm. no libido Topical progesterone the skin is rich in 5-AR, so applying progesterone to the skin should increase allopregnanolone. For example, the rate of erectile dysfunction increases from just over eight percent for men in their 40s to more than 77 percent for men aged 75 or older.